Clinical Research Directory

Inclusion Criteria: * Children from 6 months to 18 year-old. * PWS of the face * No prior treatement with PDL * Membership or beneficiary of a national insurance scheme. * Consent signed by the parents and by the patient if he is old enough to understand Exclusion Criteria: * Child with whom the angioma plan was already handled by laser or pulsed lamp * Histories of asthma or obstructive bronchitis * severe allergic Rhinitis and hyper bronchial ability to react * Bradycardie sinusale, block auriculo-ventriculaires of the second or third degree * unchecked Cardiac insufficiency * cardiogenic Shock * untreated Phéochromocytome * Sentimentality in the timolol or in one of these excipients, and\\or in the other bétabloquants * Taken by floctafénine or by sultopride * Taken of bétabloquants by oral route, of inhibitors calcic or of amiodarone * severe peripheral circulatory Disorders(Confusions of Raynaud) * arterial Low blood pressure * Pregnancy and feeding * Absence of effective contraception at the girls old enough to procreate * Contraindication in the use of cream with lidocaïne and with prilocaïne