Clinical Research Directory

Inclusion Criteria: * Sedentary adults Participants will be classified as sedentary if they have not engaged in regular physical exercise for at least one year prior to study enrollment. * Ages 45-65 * Normal blood pressure or Borderline or stage 1 hypertension Borderline hypertension will be defined as systolic blood pressure between 120-139 mmHg and/or diastolic blood pressure between 80-89 mmHg. Stage 1 hypertension will be defined as systolic blood pressure between 140-159 mmHg and/or diastolic blood pressure between 90-99 mmHg. Exclusion Criteria: * Signs or symptoms of chronic heart disease * Smoking (current or within the past 6 months) * Peripheral artery disease (ankle-brachial index\<0.9) * Diabetes (fasting blood glucose\>126 mg/L) * Orthopedic problems that would prohibit participants from participating in exercise. * Axis I psychiatric disorder * Magnetic resonance contraindications * Baseline Intellectual Quotient \< 70 * Below chance performance on the practice items of the cognitive tasks * Evidence of large vessel stroke on magnetic resonance imaging