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Multicenter Trial Estimating the Persistence of Molecular Remission in Chronic Myeloid Leukaemia in Long Term After Stopping Imatinib
Sponsor: University Hospital, Bordeaux
Summary
Background: Complete molecular remission under imatinib, therapeutic interruption possible for patients in complete remission proved in different trials. Purpose: Stopping imatinib in patients with chronic myeloid leukemia in complete molecular remission during two following years. The objectives of this study are to determine the rate of patients without a molecular relapse and so the rate of molecular relapse, to determine and to seek for clinical and biological CML-related factors predictive for a molecular relapse after imatinib discontinuation. These objectives require to increase the number of study patients to be enrolled for accurate statistical considerations. It will allow to predict which patients have to be proposed for discontinuation without risk of molecular relapse and to select the patients who need to continue or reinforce the treatment to achieve a complete long term eradication of the disease.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
220
Start Date
2011-04-06
Completion Date
2017-05-30
Last Updated
2026-07-31
Healthy Volunteers
No
Conditions
Interventions
Imatinib stop
To stop imatinib after inclusion.
Locations (32)
University Hospital Angers
Angers, France
CH Annecy
Annecy, France
CHU Bensançon
Besançon, France
Institut Bergonié
Bordeaux, France
Hôpital Morvan
Brest, France
CHU Caen
Caen, France
Hôpitaux civils de Colmar
Colmar, France
CH Sud Francilien
Corbeil-Essonnes, France
Hôpital Henri-Mondor
Créteil, France
CHU Grenoble
Grenoble, France
Centre Hospitalier - La Roche sur Yon
La Roche-sur-Yon, France
Lille University hospital - Hôpital Claude Huriez
Lille, France
CHU Dupuytren
Limoges, France
Hôpital Edouard Herriot
Lyon, France
Institut Paoli Calmette
Marseille, France
CHU Hôtel-Dieu
Nantes, France
Centre Hospitalier de Nevers
Nevers, France
CHU de Nice - Hôpital Archet 1
Nice, France
Hôpital Saint Louis
Paris, France
Hôpital Necker-Enfants Malades
Paris, France
University Hospital Bordeaux, Hôpital du Haut Lévêque
Pessac, France
University Hospital Poitiers - Hôpital Jean Bernard
Poitiers, France
Hôpital Pontchaillou
Rennes, France
Centre Henri Becquerel
Rouen, France
CH Yves Le Foll
Saint-Brieuc, France
CHR La Réunion
Saint-Denis, France
CH Régional de l'ILE DE LA REUNION/ Groupe Hospitalier Sud
Saint-Pierre, France
Hôpital Purpan
Toulouse, France
CH Valence
Valence, France
C.H.U. Brabois
Vandœuvre-lès-Nancy, France
CH Bretagne Atlantique
Vannes, France
Centre Hospitalier de Versailles - Hôpital André Mignot
Versailles, France