Clinical Research Directory

Inclusion Criteria: 1. Adults age 18 or older 2. Determined to have had at least two partial seizures by an epilepsy specialist, or to have had a single partial seizure with clinical and/or laboratory evidence of a high seizure recurrence risk 3. Monotherapy on levetiracetam less than or equal to 1500 mg/day for at least two weeks 4. Breakthrough seizure while on stable dose (\>5 days) of levetiracetam monotherapy regimen, not due to provocative factors (e.g. hypoglycemia, head trauma, missed medications) Exclusion Criteria: 1. Clinical suspicion of nonepileptic psychogenic seizures or idiopathic generalized epilepsy 2. Pregnant, child-bearing age not using contraception, or breast feeding 3. Medical contraindication to adding lacosamide 4. History of antiepileptic drug (AED) polytherapy 5. Presence of a vagus nerve stimulator 6. Creatinine clearance of less than 50 mL/min 7. Blood pressure instability: pulse \<50 or \>100, systolic blood pressure (SBP) \<50 or \>180, clinically significant electrocardiogram (EKG) abnormality 8. History of significant drug rash or anaphylactic reaction with antiepileptic drug 9. Patients with progressive lesions (e.g. brain tumors)