Clinical Research Directory

Inclusion Criteria: * Histologically confirmed low-grade gliomas OR Grade III anaplastic glioma with either or both IDH1 mutation or 1p/19q codeletion * Subject must be indicated for radiation therapy * Life expectancy greater than 5 years * Willing to participate in rigorous neurocognitive evaluations at baseline and serially following treatment * Able to speak and comprehend English * Recovered from adverse events due to agents administered more than 4 weeks before entering study * Able to undergo MRI scans Exclusion Criteria: * Prior cranial radiation therapy * Chemotherapy within 4 weeks prior to entering study * Pregnant or breastfeeding * Known brain metastases * Baseline neurocognitive or emotional disorders * Uncontrolled intercurrent illness * History of a different malignancy unless disease-free for at least 5 years * HIV positive on antiretroviral therapy