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ACTIVE NOT RECRUITING

NCT01368588

PHASE3

Androgen-Deprivation Therapy and Radiation Therapy in Treating Patients With Prostate Cancer

Sponsor: Radiation Therapy Oncology Group

View on ClinicalTrials.gov

Summary

RATIONALE: Androgens can cause the growth of prostate cancer cells. Androgen deprivation therapy may stop the adrenal glands from making androgens. Radiation therapy uses high-energy x-rays to kill tumor cells. PURPOSE: This randomized phase III trial studies androgen-deprivation therapy and radiation therapy in treating patients with prostate cancer.

Official title: Androgen Deprivation Therapy and High Dose Radiotherapy With or Without Whole-Pelvic Radiotherapy in Unfavorable Intermediate or Favorable High Risk Prostate Cancer: A Phase III Randomized Trial

Key Details

Gender

MALE

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

2592

Start Date

2011-07

Completion Date

2031-07

Last Updated

2025-10-28

Healthy Volunteers

Conditions

Prostate Cancer

Interventions

RADIATION

radiation therapy

Undergo RT using IMRT or 3D-CRT

RADIATION

Whole-pelvic radiotherapy (WPRT)

Undergo whole-pelvic radiotherapy (WPRT)

DISEASE CHARACTERISTICS: * Pathologically (histologically or cytologically) proven diagnosis of prostatic adenocarcinoma within 180 days of registration at moderate- to high-risk for recurrence as determined by one of the following combinations: * Gleason score 7-10 + T1c-T2b (palpation) + prostate-specific antigen (PSA) \< 50 ng/mL (includes intermediate- and high-risk patients) * Gleason score 6 + T2c-T4 (palpation) + PSA \< 50 ng/mL OR * Gleason score 6 + \>= 50% (positive) biopsies + PSA \< 50 ng/ml * Gleason score 6 + T1c-T2b (palpation) + PSA \> 20 ng/mL Patients previously diagnosed with low risk prostate cancer undergoing active surveillance who are re-biopsied and found to have unfavorable intermediate risk disease or favorable high risk disease according to the protocol criteria are eligible for enrollment within 180 days of the repeat biopsy procedure. * History and/or physical examination (to include at a minimum digital rectal examination of the prostate and examination of the skeletal system and abdomen) within 90 days prior to registration * Clinically negative lymph nodes as established by imaging (pelvic and/or abdominal CT or MR), (but not by nodal sampling, or dissection) within 90 days prior to registration * Patients with lymph nodes equivocal or questionable by imaging are eligible if the nodes are ≤ 1.5 cm * Patients status post a negative lymph node dissection are not eligible * No evidence of bone metastases (M0) on bone scan within 120 days prior to registration (Na F PET/CT is an acceptable substitute) * Equivocal bone scan findings are allowed if plain films (or CT or MRI) are negative for metastasis * Baseline serum PSA value performed with an FDA-approved assay (e.g., Abbott, Hybritech) within 120 days prior to registration * Study entry PSA should not be obtained during the following time frames: * Ten-day period following prostate biopsy * Following initiation of hormonal therapy * Within 30 days after discontinuation of finasteride * Within 90 days after discontinuation of dutasteride PATIENT CHARACTERISTICS: * Zubrod performance status 0-1 * Absolute neutrophil count (ANC) ≥ 1,500/mm³ * Platelet count ≥ 100,000/mm³ * Hemoglobin (Hgb) ≥ 8.0 g/dL (transfusion or other intervention to achieve Hgb ≥ 8.0 g/dL is acceptable) * No prior invasive (except non-melanoma skin cancer) malignancy unless disease-free for a minimum of 3 years (1,095 days) and not in the pelvis * E.g., carcinoma in situ of the oral cavity is permissible; however, patients with prior history of bladder cancer are not allowed * No prior hematological (e.g., leukemia, lymphoma, or myeloma) malignancy * No previous radical surgery (prostatectomy) or cryosurgery for prostate cancer * No previous pelvic irradiation, prostate brachytherapy or bilateral orchiectomy * No previous hormonal therapy, such as LHRH agonists (e.g., leuprolide, goserelin, buserelin, triptorelin) or LHRH antagonist (e.g. degarelix), anti-androgens (e.g., flutamide, bicalutamide, cyproterone acetate), estrogens (e.g., DES), or surgical castration (orchiectomy) * Prior pharmacologic androgen ablation for prostate cancer is allowed only if the onset of androgen ablation (both LHRH agonist and oral anti-androgen) is ≤ 45 days prior to the date of registration. * No severe, active co-morbidity, defined as any of the following: * Unstable angina and/or congestive heart failure requiring hospitalization within the last 6 months * Transmural myocardial infarction within the last 6 months * Acute bacterial or fungal infection requiring intravenous antibiotics at the time of registration * Chronic obstructive pulmonary disease exacerbation or other respiratory illness requiring hospitalization or precluding study therapy at the time of registration * Hepatic insufficiency resulting in clinical jaundice and/or coagulation defects or severe liver dysfunction * Acquired immune deficiency syndrome (AIDS) based upon current Centers for Disease Control (CDC) definition * Protocol-specific requirements may also exclude immuno-compromised patients * HIV testing is not required for entry into this protocol * No patients who are sexually active and not willing/able to use medically acceptable forms of contraception * No prior allergic reaction to the hormones involved in this protocol PRIOR CONCURRENT THERAPY: * See Disease Characteristics * No prior radical surgery (prostatectomy) or cryosurgery for prostate cancer * No prior pelvic irradiation, prostate brachytherapy, or bilateral orchiectomy * No prior hormonal therapy, such as luteinizing hormone-releasing hormone (LHRH) agonists (e.g., leuprolide, goserelin, buserelin, triptorelin) or LHRH antagonist (e.g., degarelix), anti-androgens (e.g., flutamide, bicalutamide, cyproterone acetate), estrogens (e.g., diethylstilbestrol (DES) ), or surgical castration (orchiectomy) * No prior pharmacologic androgen ablation for prostate cancer unless the onset of androgen ablation is ≤ 45 days prior to the date of registration * No finasteride within 30 days prior to registration * No dutasteride or dutasteride/tamsulosin (Jalyn) within 90 days prior to registration * No prior or concurrent cytotoxic chemotherapy for prostate cancer * Prior chemotherapy for a different cancer is allowable * No prior radiotherapy, including brachytherapy, to the region of the study cancer that would result in overlap of radiation therapy fields

Locations (478)

University of South Alabama Mitchell Cancer Institute

Mobile, Alabama, United States

Anchorage Associates in Radiation Medicine

Anchorage, Alaska, United States

Alaska Oncology and Hematology LLC

Anchorage, Alaska, United States

Anchorage Oncology Centre

Anchorage, Alaska, United States

Katmai Oncology Group

Anchorage, Alaska, United States

Providence Alaska Medical Center

Anchorage, Alaska, United States

Fairbanks Memorial Hospital

Fairbanks, Alaska, United States

Arizona Breast Cancer Specialists-Gilbert

Gilbert, Arizona, United States

Arizona Center for Cancer Care-Peoria

Peoria, Arizona, United States

Cancer Center at Saint Joseph's

Phoenix, Arizona, United States

Saint Joseph's Hospital and Medical Center

Phoenix, Arizona, United States

Arizona Breast Cancer Specialists-Phoenix

Phoenix, Arizona, United States

Arizona Oncology-Deer Valley Center

Phoenix, Arizona, United States

21st Century Oncology-Scottsdale

Scottsdale, Arizona, United States

Arizona Breast Cancer Specialists

Scottsdale, Arizona, United States

Arizona Breast Cancer Specialists-Scottsdale

Scottsdale, Arizona, United States

Arizona Oncology Services Foundation

Scottsdale, Arizona, United States

Arizona Center for Cancer Care-Surprise

Surprise, Arizona, United States

Arizona Oncology Associates-West Orange Grove

Tucson, Arizona, United States

University of Arizona Cancer Center-Orange Grove Campus

Tucson, Arizona, United States

Banner University Medical Center - Tucson

Tucson, Arizona, United States

University of Arizona Cancer Center-North Campus

Tucson, Arizona, United States

CHI Saint Vincent Cancer Center Hot Springs

Hot Springs, Arkansas, United States

Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro

Jonesboro, Arkansas, United States

University of Arkansas for Medical Sciences

Little Rock, Arkansas, United States

Sutter Cancer Centers Radiation Oncology Services-Auburn

Auburn, California, United States

AIS Cancer Center at San Joaquin Community Hospital

Bakersfield, California, United States

Alta Bates Summit Medical Center-Herrick Campus

Berkeley, California, United States

Providence Saint Joseph Medical Center/Disney Family Cancer Center

Burbank, California, United States

Sutter Cancer Centers Radiation Oncology Services-Cameron Park

Cameron Park, California, United States

Mercy San Juan Medical Center

Carmichael, California, United States

Adventist Health Cancer Care Center Chico

Chico, California, United States

Fresno Cancer Center

Fresno, California, United States

Saint Agnes Medical Center

Fresno, California, United States

Marin General Hospital

Greenbrae, California, United States

UC San Diego Moores Cancer Center

La Jolla, California, United States

Tibor Rubin VA Medical Center

Long Beach, California, United States

Los Angeles County-USC Medical Center

Los Angeles, California, United States

USC / Norris Comprehensive Cancer Center

Los Angeles, California, United States

Cedars Sinai Medical Center

Los Angeles, California, United States

Fremont - Rideout Cancer Center

Marysville, California, United States

Mercy UC Davis Cancer Center

Merced, California, United States

Memorial Medical Center

Modesto, California, United States

Alta Bates Summit Medical Center - Summit Campus

Oakland, California, United States

Kaiser Permanente Oakland-Broadway

Oakland, California, United States

Desert Regional Medical Center

Palm Springs, California, United States

Palo Alto Medical Foundation Health Care

Palo Alto, California, United States

Stanford Cancer Institute Palo Alto

Palo Alto, California, United States

Pomona Valley Hospital Medical Center

Pomona, California, United States

Kaiser Permanente-Rancho Cordova Cancer Center

Rancho Cordova, California, United States

Rohnert Park Cancer Center

Rohnert Park, California, United States

Sutter Cancer Centers Radiation Oncology Services-Roseville

Roseville, California, United States

The Permanente Medical Group-Roseville Radiation Oncology

Roseville, California, United States

Mercy Cancer Center - Sacramento

Sacramento, California, United States

Sutter Medical Center Sacramento

Sacramento, California, United States

University of California Davis Comprehensive Cancer Center

Sacramento, California, United States

South Sacramento Cancer Center

Sacramento, California, United States

UCSF Medical Center-Mount Zion

San Francisco, California, United States

UCSF Medical Center-Mission Bay

San Francisco, California, United States

Santa Clara Valley Medical Center

San Jose, California, United States

Kaiser Permanente Medical Center - Santa Clara

Santa Clara, California, United States

Kaiser Permanente Cancer Treatment Center

South San Francisco, California, United States

Saint Joseph's Medical Center

Stockton, California, United States

Palo Alto Medical Foundation-Sunnyvale

Sunnyvale, California, United States

Gene Upshaw Memorial Tahoe Forest Cancer Center

Truckee, California, United States

Sutter Cancer Centers Radiation Oncology Services-Vacaville

Vacaville, California, United States

Rocky Mountain Cancer Centers-Aurora

Aurora, Colorado, United States

University of Colorado Hospital

Aurora, Colorado, United States

Rocky Mountain Cancer Centers-Boulder

Boulder, Colorado, United States

UCHealth Memorial Hospital Central

Colorado Springs, Colorado, United States

Porter Adventist Hospital

Denver, Colorado, United States

Shaw Cancer Center

Edwards, Colorado, United States

North Colorado Medical Center

Greeley, Colorado, United States

Longmont United Hospital

Longmont, Colorado, United States

McKee Medical Center

Loveland, Colorado, United States

Parker Adventist Hospital

Parker, Colorado, United States

Hartford HealthCare - Saint Vincent's Medical Center

Bridgeport, Connecticut, United States

Smilow Cancer Hospital Care Center at Saint Francis

Hartford, Connecticut, United States

Middlesex Hospital

Middletown, Connecticut, United States

Helen F Graham Cancer Center

Newark, Delaware, United States

Christiana Care Health System-Christiana Hospital

Newark, Delaware, United States

Beebe Health Campus

Rehoboth Beach, Delaware, United States

TidalHealth Nanticoke / Allen Cancer Center

Seaford, Delaware, United States

MedStar Washington Hospital Center

Washington D.C., District of Columbia, United States

Broward Health North

Deerfield Beach, Florida, United States

Baptist MD Anderson Cancer Center

Jacksonville, Florida, United States

Baptist Medical Center South

Jacksonville, Florida, United States

Jupiter Medical Center

Jupiter, Florida, United States

University of Miami Miller School of Medicine-Sylvester Cancer Center

Miami, Florida, United States

Orlando Health Cancer Institute

Orlando, Florida, United States

Cancer Center of Putnam

Palatka, Florida, United States

GenesisCare USA - Plantation

Plantation, Florida, United States

James A. Haley Veterans Affairs Hospital

Tampa, Florida, United States

Florida Cancer Affiliates

Trinity, Florida, United States

Cleveland Clinic-Weston

Weston, Florida, United States

Grady Health System

Atlanta, Georgia, United States

Emory University Hospital Midtown

Atlanta, Georgia, United States

Piedmont Hospital

Atlanta, Georgia, United States

Emory University Hospital/Winship Cancer Institute

Atlanta, Georgia, United States

Emory Saint Joseph's Hospital

Atlanta, Georgia, United States

John B Amos Cancer Center

Columbus, Georgia, United States

Atlanta VA Medical Center

Decatur, Georgia, United States

Piedmont Fayette Hospital

Fayetteville, Georgia, United States

Northeast Georgia Medical Center-Gainesville

Gainesville, Georgia, United States

Central Georgia Gynecologic Oncology

Macon, Georgia, United States

Lewis Cancer and Research Pavilion at Saint Joseph's/Candler

Savannah, Georgia, United States

Queen's Medical Center

Honolulu, Hawaii, United States

The Cancer Center of Hawaii-Liliha

Honolulu, Hawaii, United States

The Cancer Center of Hawaii-Pali Momi

‘Aiea, Hawaii, United States

Saint Alphonsus Cancer Care Center-Boise

Boise, Idaho, United States

Kootenai Health - Coeur d'Alene

Coeur d'Alene, Idaho, United States

Idaho Urologic Institute-Meridian

Meridian, Idaho, United States

Kootenai Clinic Cancer Services - Post Falls

Post Falls, Idaho, United States

Kootenai Cancer Clinic

Sandpoint, Idaho, United States

Saint Luke's Cancer Institute - Twin Falls

Twin Falls, Idaho, United States

Northwest Community Hospital

Arlington Heights, Illinois, United States

Rush - Copley Medical Center

Aurora, Illinois, United States

John H Stroger Jr Hospital of Cook County

Chicago, Illinois, United States

Rush University Medical Center

Chicago, Illinois, United States

Weiss Memorial Hospital

Chicago, Illinois, United States

Advocate Illinois Masonic Medical Center

Chicago, Illinois, United States

UChicago Medicine Comprehensive Cancer Center - Saint Joseph Hospital

Chicago, Illinois, United States

Decatur Memorial Hospital

Decatur, Illinois, United States

Crossroads Cancer Center

Effingham, Illinois, United States

Loyola University Medical Center

Maywood, Illinois, United States

OSF Saint Francis Radiation Oncology at Peoria Cancer Center

Peoria, Illinois, United States

OSF Saint Francis Medical Center

Peoria, Illinois, United States

SwedishAmerican Regional Cancer Center/ACT

Rockford, Illinois, United States

Saint John's Hospital

Springfield, Illinois, United States

Memorial Medical Center

Springfield, Illinois, United States

Southwest Illinois Health Services LLP

Swansea, Illinois, United States

Carle Cancer Center

Urbana, Illinois, United States

Radiation Oncology Associates PC

Fort Wayne, Indiana, United States

Parkview Hospital Randallia

Fort Wayne, Indiana, United States

Parkview Regional Medical Center

Fort Wayne, Indiana, United States

Indiana University/Melvin and Bren Simon Cancer Center

Indianapolis, Indiana, United States

IU Health Methodist Hospital

Indianapolis, Indiana, United States

Memorial Hospital of South Bend

South Bend, Indiana, United States

McFarland Clinic PC - Ames

Ames, Iowa, United States

Saint Luke's Hospital

Cedar Rapids, Iowa, United States

Mercy Hospital

Cedar Rapids, Iowa, United States

Finley Hospital

Dubuque, Iowa, United States

Central Care Cancer Center - Garden City

Garden City, Kansas, United States

Saint Catherine Hospital

Garden City, Kansas, United States

University of Kansas Cancer Center

Kansas City, Kansas, United States

Lawrence Memorial Hospital

Lawrence, Kansas, United States

Olathe Health Cancer Center

Olathe, Kansas, United States

University of Kansas Cancer Center-Overland Park

Overland Park, Kansas, United States

Cotton O'Neil Cancer Center / Stormont Vail Health

Topeka, Kansas, United States

Ascension Via Christi Hospitals Wichita

Wichita, Kansas, United States

University of Kentucky/Markey Cancer Center

Lexington, Kentucky, United States

Owensboro Health Mitchell Memorial Cancer Center

Owensboro, Kentucky, United States

Mary Bird Perkins Cancer Center

Baton Rouge, Louisiana, United States

Mary Bird Perkins Cancer Center - Covington

Covington, Louisiana, United States

Mary Bird Perkins Cancer Center - Houma

Houma, Louisiana, United States

East Jefferson General Hospital

Metairie, Louisiana, United States

LSU Healthcare Network / Metairie Multi-Specialty Clinic

Metairie, Louisiana, United States

Tulane University Health Sciences Center

New Orleans, Louisiana, United States

Touro Infirmary

New Orleans, Louisiana, United States

Ochsner Medical Center Jefferson

New Orleans, Louisiana, United States

Anne Arundel Medical Center

Annapolis, Maryland, United States

University of Maryland/Greenebaum Cancer Center

Baltimore, Maryland, United States

Greater Baltimore Medical Center

Baltimore, Maryland, United States

Saint Agnes Hospital

Baltimore, Maryland, United States

UM Upper Chesapeake Medical Center

Bel Air, Maryland, United States

Central Maryland Radiation Oncology in Howard County

Columbia, Maryland, United States

University of Maryland Radiation Oncology Center at Union Hospital

Elkton, Maryland, United States

UM Baltimore Washington Medical Center/Tate Cancer Center

Glen Burnie, Maryland, United States

TidalHealth Peninsula Regional

Salisbury, Maryland, United States

UM Saint Joseph Medical Center

Towson, Maryland, United States

Massachusetts General Hospital Cancer Center

Boston, Massachusetts, United States

Saint Anne's Hospital

Fall River, Massachusetts, United States

Cape Cod Hospital

Hyannis, Massachusetts, United States

Lowell General Hospital

Lowell, Massachusetts, United States

Beth Israel Deaconess Hospital-Plymouth

Plymouth, Massachusetts, United States

Bixby Medical Center

Adrian, Michigan, United States

Veteran's Administration Medical Center - Ann Arbor

Ann Arbor, Michigan, United States

Saint Joseph Mercy Hospital

Ann Arbor, Michigan, United States

University of Michigan Comprehensive Cancer Center

Ann Arbor, Michigan, United States

Bronson Battle Creek

Battle Creek, Michigan, United States

McLaren Cancer Institute-Bay City

Bay City, Michigan, United States

Henry Ford Cancer Institute-Downriver

Brownstown, Michigan, United States

GenesisCare USA - Clarkston

Clarkston, Michigan, United States

McLaren Cancer Institute-Clarkston

Clarkston, Michigan, United States

Henry Ford Macomb Hospital-Clinton Township

Clinton Township, Michigan, United States

Beaumont Hospital - Dearborn

Dearborn, Michigan, United States

Wayne State University/Karmanos Cancer Institute

Detroit, Michigan, United States

Henry Ford Hospital

Detroit, Michigan, United States

Ascension Saint John Hospital

Detroit, Michigan, United States

GenesisCare USA - Farmington Hills

Farmington Hills, Michigan, United States

Weisberg Cancer Treatment Center

Farmington Hills, Michigan, United States

Beaumont Hospital - Farmington Hills

Farmington Hills, Michigan, United States

McLaren Cancer Institute-Flint

Flint, Michigan, United States

Mercy Health Saint Mary's

Grand Rapids, Michigan, United States

Spectrum Health at Butterworth Campus

Grand Rapids, Michigan, United States

West Michigan Cancer Center

Kalamazoo, Michigan, United States

Karmanos Cancer Institute at McLaren Greater Lansing

Lansing, Michigan, United States

Sparrow Hospital

Lansing, Michigan, United States

McLaren Cancer Institute-Lapeer Region

Lapeer, Michigan, United States

Saint Mary Mercy Hospital

Livonia, Michigan, United States

McLaren Cancer Institute-Macomb

Mount Clemens, Michigan, United States

McLaren Cancer Institute-Central Michigan

Mount Pleasant, Michigan, United States

Mercy Health Mercy Campus

Muskegon, Michigan, United States

McLaren Cancer Institute-Owosso

Owosso, Michigan, United States

McLaren Cancer Institute-Northern Michigan

Petoskey, Michigan, United States

21st Century Oncology-Pontiac

Pontiac, Michigan, United States

Saint Joseph Mercy Oakland

Pontiac, Michigan, United States

McLaren-Port Huron

Port Huron, Michigan, United States

William Beaumont Hospital-Royal Oak

Royal Oak, Michigan, United States

Ascension Saint Mary's Hospital

Saginaw, Michigan, United States

Lakeland Medical Center Saint Joseph

Saint Joseph, Michigan, United States

William Beaumont Hospital - Troy

Troy, Michigan, United States

GenesisCare USA - Troy

Troy, Michigan, United States

Saint John Macomb-Oakland Hospital

Warren, Michigan, United States

Henry Ford West Bloomfield Hospital

West Bloomfield, Michigan, United States

Metro Health Hospital

Wyoming, Michigan, United States

Mayo Clinic Health System in Albert Lea

Albert Lea, Minnesota, United States

Sanford Joe Lueken Cancer Center

Bemidji, Minnesota, United States

Saint Luke's Hospital of Duluth

Duluth, Minnesota, United States

Mayo Clinic Health Systems-Mankato

Mankato, Minnesota, United States

Hennepin County Medical Center

Minneapolis, Minnesota, United States

Monticello Cancer Center

Monticello, Minnesota, United States

Coborn Cancer Center at Saint Cloud Hospital

Saint Cloud, Minnesota, United States

Park Nicollet Clinic - Saint Louis Park

Saint Louis Park, Minnesota, United States

Regions Hospital

Saint Paul, Minnesota, United States

Rice Memorial Hospital

Willmar, Minnesota, United States

University of Mississippi Medical Center

Jackson, Mississippi, United States

Singing River Hospital

Pascagoula, Mississippi, United States

Saint Francis Medical Center

Cape Girardeau, Missouri, United States

Southeast Cancer Center

Cape Girardeau, Missouri, United States

Siteman Cancer Center at Saint Peters Hospital

City of Saint Peters, Missouri, United States

Siteman Cancer Center at West County Hospital

Creve Coeur, Missouri, United States

Freeman Health System

Joplin, Missouri, United States

North Kansas City Hospital

Kansas City, Missouri, United States

Kansas City Veterans Affairs Medical Center

Kansas City, Missouri, United States

The University of Kansas Cancer Center-South

Kansas City, Missouri, United States

University of Kansas Cancer Center - North

Kansas City, Missouri, United States

University of Kansas Cancer Center - Lee's Summit

Lee's Summit, Missouri, United States

Delbert Day Cancer Institute at PCRMC

Rolla, Missouri, United States

Heartland Regional Medical Center

Saint Joseph, Missouri, United States

CoxHealth South Hospital

Springfield, Missouri, United States

Washington University School of Medicine

St Louis, Missouri, United States

Veteran's Affairs Medical Center - Saint Louis

St Louis, Missouri, United States

Siteman Cancer Center-South County

St Louis, Missouri, United States

Missouri Baptist Medical Center

St Louis, Missouri, United States

Mercy Hospital Saint Louis

St Louis, Missouri, United States

Billings Clinic Cancer Center

Billings, Montana, United States

Benefis Healthcare- Sletten Cancer Institute

Great Falls, Montana, United States

Alegent Health Bergan Mercy Medical Center

Omaha, Nebraska, United States

University of Nebraska Medical Center

Omaha, Nebraska, United States

Renown Regional Medical Center

Reno, Nevada, United States

Exeter Hospital

Exeter, New Hampshire, United States

Dartmouth Hitchcock Medical Center

Lebanon, New Hampshire, United States

AtlantiCare Surgery Center

Egg Harbor, New Jersey, United States

Virtua Memorial

Mount Holly, New Jersey, United States

Inspira Medical Center Mullica Hill

Mullica Hill, New Jersey, United States

Penn Medicine Princeton Health

Plainsboro, New Jersey, United States

Sidney Kimmel Cancer Center Washington Township

Sewell, New Jersey, United States

Robert Wood Johnson University Hospital Somerset

Somerville, New Jersey, United States

Sparta Cancer Treatment Center

Sparta, New Jersey, United States

Inspira Medical Center Vineland

Vineland, New Jersey, United States

Virtua Voorhees

Voorhees Township, New Jersey, United States

Memorial Medical Center - Las Cruces

Las Cruces, New Mexico, United States

South Shore University Hospital

Bay Shore, New York, United States

New York-Presbyterian/Brooklyn Methodist Hospital

Brooklyn, New York, United States

Sands Cancer Center

Canandaigua, New York, United States

Mary Imogene Bassett Hospital

Cooperstown, New York, United States

Arnot Ogden Medical Center/Falck Cancer Center

Elmira, New York, United States

Northwell Health/Center for Advanced Medicine

Lake Success, New York, United States

Long Island Jewish Medical Center

New Hyde Park, New York, United States

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center

New York, New York, United States

Wilmot Cancer Institute Radiation Oncology at Greece

Rochester, New York, United States

Highland Hospital

Rochester, New York, United States

University of Rochester

Rochester, New York, United States

Stony Brook University Medical Center

Stony Brook, New York, United States

James J Peters VA Medical Center

The Bronx, New York, United States

UNC Lineberger Comprehensive Cancer Center

Chapel Hill, North Carolina, United States

Durham VA Medical Center

Durham, North Carolina, United States

Duke University Medical Center

Durham, North Carolina, United States

The Coleman Radiation Center-Carteret General Hospital

Morehead City, North Carolina, United States

FirstHealth of the Carolinas-Moore Regional Hospital

Pinehurst, North Carolina, United States

UNC Rex Cancer Center

Raleigh, North Carolina, United States

NHRMC Radiation Oncology - Supply

Supply, North Carolina, United States

NHRMC Radiation Oncology - 16th Street

Wilmington, North Carolina, United States

Novant Health Forsyth Medical Center

Winston-Salem, North Carolina, United States

Wake Forest University Health Sciences

Winston-Salem, North Carolina, United States

Sanford Broadway Medical Center

Fargo, North Dakota, United States

Summa Health System - Akron Campus

Akron, Ohio, United States

Cleveland Clinic Akron General

Akron, Ohio, United States

Summa Health System - Barberton Campus

Barberton, Ohio, United States

UHHS-Chagrin Highlands Medical Center

Beachwood, Ohio, United States

Cleveland Clinic Mercy Hospital

Canton, Ohio, United States

Geauga Hospital

Chardon, Ohio, United States

Adena Regional Medical Center

Chillicothe, Ohio, United States

Case Western Reserve University

Cleveland, Ohio, United States

Cleveland Clinic Cancer Center/Fairview Hospital

Cleveland, Ohio, United States

Cleveland Clinic Foundation

Cleveland, Ohio, United States

Ohio State University Comprehensive Cancer Center

Columbus, Ohio, United States

The Mark H Zangmeister Center

Columbus, Ohio, United States

Mount Carmel Health Center West

Columbus, Ohio, United States

Mercy Cancer Center-Elyria

Elyria, Ohio, United States

Cleveland Clinic Cancer Center Independence

Independence, Ohio, United States

Cleveland Clinic Cancer Center Mansfield

Mansfield, Ohio, United States

Toledo Clinic Cancer Centers-Maumee

Maumee, Ohio, United States

Hillcrest Hospital Cancer Center

Mayfield Heights, Ohio, United States

Summa Health Medina Medical Center

Medina, Ohio, United States

UH Seidman Cancer Center at Lake Health Mentor Campus

Mentor, Ohio, United States

UH Seidman Cancer Center at Southwest General Hospital

Middleburg Heights, Ohio, United States

Saint Charles Hospital

Oregon, Ohio, United States

University Hospitals Parma Medical Center

Parma, Ohio, United States

Southern Ohio Medical Center

Portsmouth, Ohio, United States

University Hospitals Portage Medical Center

Ravenna, Ohio, United States

UH Seidman Cancer Center at Salem Regional Medical Center

Salem, Ohio, United States

North Coast Cancer Care

Sandusky, Ohio, United States

UH Seidman Cancer Center at Firelands Regional Medical Center

Sandusky, Ohio, United States

Cleveland Clinic Cancer Center Strongsville

Strongsville, Ohio, United States

ProMedica Flower Hospital

Sylvania, Ohio, United States

University of Toledo

Toledo, Ohio, United States

Mercy Health - Saint Anne Hospital

Toledo, Ohio, United States

UHHS-Westlake Medical Center

Westlake, Ohio, United States

Cancer Treatment Center

Wooster, Ohio, United States

Cleveland Clinic Wooster Family Health and Surgery Center

Wooster, Ohio, United States

Wright-Patterson Medical Center

Wright-Patterson Air Force Base, Ohio, United States

Genesis Healthcare System Cancer Care Center

Zanesville, Ohio, United States

University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, United States

Saint John Medical Center

Tulsa, Oklahoma, United States

Clackamas Radiation Oncology Center

Clackamas, Oregon, United States

Three Rivers Community Hospital

Grants Pass, Oregon, United States

Providence Medford Medical Center

Medford, Oregon, United States

Rogue Valley Medical Center

Medford, Oregon, United States

Providence Portland Medical Center

Portland, Oregon, United States

Providence Saint Vincent Medical Center

Portland, Oregon, United States

Kaiser Permanente Northwest

Portland, Oregon, United States

Jefferson Abington Hospital

Abington, Pennsylvania, United States

Lehigh Valley Hospital-Cedar Crest

Allentown, Pennsylvania, United States

Geisinger Medical Center

Danville, Pennsylvania, United States

Northeast Radiation Oncology Center

Dunmore, Pennsylvania, United States

Ephrata Cancer Center

Ephrata, Pennsylvania, United States

Fox Chase Cancer Center Buckingham

Furlong, Pennsylvania, United States

Adams Cancer Center

Gettysburg, Pennsylvania, United States

Cherry Tree Cancer Center

Hanover, Pennsylvania, United States

Penn State Milton S Hershey Medical Center

Hershey, Pennsylvania, United States

Sechler Family Cancer Center

Lebanon, Pennsylvania, United States

Upper Delaware Valley Cancer Center

Milford, Pennsylvania, United States

Fox Chase Cancer Center

Philadelphia, Pennsylvania, United States

VA Pittsburgh Healthcare System

Pittsburgh, Pennsylvania, United States

Reading Hospital

West Reading, Pennsylvania, United States

Geisinger Wyoming Valley/Henry Cancer Center

Wilkes-Barre, Pennsylvania, United States

Asplundh Cancer Pavilion

Willow Grove, Pennsylvania, United States

WellSpan Health-York Hospital

York, Pennsylvania, United States

AnMed Health Cancer Center

Anderson, South Carolina, United States

Prisma Health Cancer Institute - Spartanburg

Boiling Springs, South Carolina, United States

Medical University of South Carolina

Charleston, South Carolina, United States

Tidelands Georgetown Memorial Hospital

Georgetown, South Carolina, United States

Prisma Health Cancer Institute - Faris

Greenville, South Carolina, United States

Saint Francis Cancer Center

Greenville, South Carolina, United States

Prisma Health Cancer Institute - Eastside

Greenville, South Carolina, United States

Self Regional Healthcare

Greenwood, South Carolina, United States

Prisma Health Cancer Institute - Greer

Greer, South Carolina, United States

Gibbs Cancer Center-Pelham

Greer, South Carolina, United States

The Radiation Oncology Center-Hilton Head/Bluffton

Hilton Head Island, South Carolina, United States

Prisma Health Cancer Institute - Seneca

Seneca, South Carolina, United States

Spartanburg Medical Center

Spartanburg, South Carolina, United States

Sanford USD Medical Center - Sioux Falls

Sioux Falls, South Dakota, United States

Erlanger Medical Center

Chattanooga, Tennessee, United States

Wellmont Holston Valley Hospital and Medical Center

Kingsport, Tennessee, United States

Vanderbilt University/Ingram Cancer Center

Nashville, Tennessee, United States

Texas Cancer Center

Abilene, Texas, United States

Texas Oncology PA Beaumont

Beaumont, Texas, United States

UT Southwestern/Simmons Cancer Center-Dallas

Dallas, Texas, United States

Texas Oncology - Denison Cancer Center

Denison, Texas, United States

Brooke Army Medical Center

Fort Sam Houston, Texas, United States

Texas Oncology - Fort Worth Cancer Center

Fort Worth, Texas, United States

University of Texas Medical Branch

Galveston, Texas, United States

Memorial Hermann Memorial City Medical Center

Houston, Texas, United States

Ben Taub General Hospital

Houston, Texas, United States

UTMB Cancer Center at Victory Lakes

League City, Texas, United States

Texas Oncology-McAllen

McAllen, Texas, United States

Texas Oncology-McKinney

McKinney, Texas, United States

West Texas Cancer Center

Odessa, Texas, United States

Texas Oncology-Plano West

Plano, Texas, United States

University of Texas Health Science Center at San Antonio

San Antonio, Texas, United States

Texas Oncology Cancer Center Sugar Land

Sugar Land, Texas, United States

Deke Slayton Cancer Center

Webster, Texas, United States

American Fork Hospital / Huntsman Intermountain Cancer Center

American Fork, Utah, United States

Sandra L Maxwell Cancer Center

Cedar City, Utah, United States

Intermountain Medical Center

Murray, Utah, United States

McKay-Dee Hospital Center

Ogden, Utah, United States

Ogden Regional Medical Center

Ogden, Utah, United States

Utah Valley Regional Medical Center

Provo, Utah, United States

Utah Cancer Specialists-Salt Lake City

Salt Lake City, Utah, United States

Huntsman Cancer Institute/University of Utah

Salt Lake City, Utah, United States

Dixie Medical Center Regional Cancer Center

St. George, Utah, United States

Southwestern Vermont Medical Center

Bennington, Vermont, United States

Central Vermont Medical Center/National Life Cancer Treatment

Berlin Corners, Vermont, United States

University of Vermont Medical Center

Burlington, Vermont, United States

Norris Cotton Cancer Center-North

Saint Johnsbury, Vermont, United States

University of Virginia Cancer Center

Charlottesville, Virginia, United States

Augusta Health Center for Cancer and Blood Disorders

Fishersville, Virginia, United States

Sentara Cancer Institute at Sentara CarePlex Hospital

Hampton, Virginia, United States

Sentara Rockingham Memorial Hospital Hahn Cancer Center

Harrisonburg, Virginia, United States

Bon Secours DePaul Medical Center

Norfolk, Virginia, United States

Sentara Norfolk General Hospital

Norfolk, Virginia, United States

Naval Medical Center - Portsmouth

Portsmouth, Virginia, United States

Hunter Holmes McGuire Veterans Administration Medical Center

Richmond, Virginia, United States

Oncology and Hematology Associates of Southwest Virginia

Roanoke, Virginia, United States

Sentara Obici Hospital

Suffolk, Virginia, United States

Sentara Virginia Beach General Hospital

Virginia Beach, Virginia, United States

Saint Francis Hospital

Federal Way, Washington, United States

Virginia Mason Medical Center

Seattle, Washington, United States

Madigan Army Medical Center

Tacoma, Washington, United States

PeaceHealth Southwest Medical Center

Vancouver, Washington, United States

North Star Lodge Cancer Center at Yakima Valley Memorial Hospital

Yakima, Washington, United States

United Hospital Center

Bridgeport, West Virginia, United States

West Virginia University Healthcare

Morgantown, West Virginia, United States

Langlade Hospital and Cancer Center

Antigo, Wisconsin, United States

ThedaCare Regional Cancer Center

Appleton, Wisconsin, United States

ThedaCare Regional Medical Center - Appleton

Appleton, Wisconsin, United States

Ascension Southeast Wisconsin Hospital - Elmbrook Campus

Brookfield, Wisconsin, United States

Marshfield Medical Center-EC Cancer Center

Eau Claire, Wisconsin, United States

Mayo Clinic Health System Eau Claire Hospital-Luther Campus

Eau Claire, Wisconsin, United States

Ascension Saint Francis - Reiman Cancer Center

Franklin, Wisconsin, United States

Saint Vincent Hospital Cancer Center Green Bay

Green Bay, Wisconsin, United States

Saint Vincent Hospital Cancer Center at Saint Mary's

Green Bay, Wisconsin, United States

Aurora BayCare Medical Center

Green Bay, Wisconsin, United States

UW Cancer Center Johnson Creek

Johnson Creek, Wisconsin, United States

Gundersen Lutheran Medical Center

La Crosse, Wisconsin, United States

Mayo Clinic Health System-Franciscan Healthcare

La Crosse, Wisconsin, United States

University of Wisconsin Hospital and Clinics

Madison, Wisconsin, United States

Aurora Bay Area Medical Group-Marinette

Marinette, Wisconsin, United States

Bay Area Medical Center

Marinette, Wisconsin, United States

Marshfield Medical Center-Marshfield

Marshfield, Wisconsin, United States

Froedtert Menomonee Falls Hospital

Menomonee Falls, Wisconsin, United States

Ascension Columbia Saint Mary's Hospital Ozaukee

Mequon, Wisconsin, United States

Ascension Southeast Wisconsin Hospital - Saint Joseph Campus