Clinical Research Directory

Inclusion Criteria: * stable dose of opioids for at least 12 weeks before screening visit * less than or equal to 5 spontaneous bowel movements for a 2 week period and experiencing at least one other symptom of constipation * willing to stop laxatives and other bowel treatments; rescue laxative allowed Exclusion Criteria: * Clinically significant condition or illness (other than the condition for which the pain medication was prescribed) * Have participated in another clinical trial of an investigational drug 30 days prior to screening * History of cancer treatment except adequately treated localized skin cancer within 5 years of screening * History of chronic constipation prior to opioid therapy * Females who are pregnant or breast feeding * Have any condition that may affect drug absorption (e.g. previous GI surgery)