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Catheter Ablation Versus Medical Treatment of AF in Heart Failure
Sponsor: Barts & The London NHS Trust
Summary
Heart failure and atrial fibrillation (AF) often coexist, and each increases the morbidity and mortality associated with the other. The investigators hypothesized that restoration of normal sinus rhythm by catheter ablation is superior to medical treatment of AF in heart failure. This study randomizes patients with heart failure and persistent AF to medical treatment of AF or catheter ablation to restore sinus rhythm.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
50
Start Date
2005-03
Completion Date
2013-02
Last Updated
2026-09-21
Healthy Volunteers
No
Conditions
Interventions
Catheter ablation of persistent atrial fibrillation
Catheter ablation of AF as described previously by our group (e.g. Hunter et al, Heart 2010).
Medical treatment alone
Medical treatment of persistent AF as 'normal care'. Patients are randomised to medical treatment alone for atrial fibrillation. Treatment will be as per current guidelines for persistent atrial fibrillation, with rate control as first line (using beta-blockers, calcium channel blockers and digoxin as indicated) and rhythm control as second line (using sotalol, dronedarone, or amiodarone as indicated). (Both groups will receive standard heart failure medication including angiotensin converting enzyme inhibitors, beta blockers, aldosterone antagonists, and diuretics as indicated).
Locations (1)
Barts & The London NHS Trust
London, UK, United Kingdom