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The Hurria Older PatiEnts (HOPE) With Breast Cancer Study
Sponsor: City of Hope Medical Center
Summary
The goal of this study is to develop a "bedside to bench" model of clinical and biological predictors for toxicity to adjuvant and neoadjuvant chemotherapy in older adults with breast cancer. The investigators will develop a predictive model using clinical and biological predictors of toxicity to adjuvant and neoadjuvant chemotherapy in older adults with breast cancer. The investigators will also determine the association between clinical and biological factors and reduced relative dose intensity of the prescribed chemotherapy regimen. In addition, the investigators will explore specific chemotherapy toxicities associated with reduced relative dose intensity of a prescribed regimen.
Official title: Clinical and Biological Predictors of Chemotherapy Toxicity in Older Adults
Key Details
Gender
All
Age Range
65 Years - Any
Study Type
OBSERVATIONAL
Enrollment
700
Start Date
2011-09-09
Completion Date
2026-09-18
Last Updated
2025-11-10
Healthy Volunteers
Yes
Conditions
Locations (17)
City of Hope Medical Center
Duarte, California, United States
Yale University
New Haven, Connecticut, United States
University of Chicago
Chicago, Illinois, United States
Massachusetts General Hospital
Boston, Massachusetts, United States
Dana-Farber Cancer Institute
Boston, Massachusetts, United States
Washington University St. Louis
St Louis, Missouri, United States
Roswell Park Cancer Institute
Buffalo, New York, United States
Hofstra-North-LIJ Cancer Institute
New Hyde Park, New York, United States
Memorial Sloan-Kettering Cancer Center
New York, New York, United States
University of Rochester Medical Center
Rochester, New York, United States
University of North Carolina
Chapel Hill, North Carolina, United States
Wake Forest University
Winston-Salem, North Carolina, United States
Case Western Reserve University
Cleveland, Ohio, United States
Thomas Jefferson University
Philadelphia, Pennsylvania, United States
Fox Chase Cancer Center
Philadelphia, Pennsylvania, United States
Rhode Island Hospital
Providence, Rhode Island, United States
University of Virginia Health System
Charlottesville, Virginia, United States