Clinical Research Directory

Inclusion Criteria: * Patients with diagnosed with secondary hepatic malignancy; * Patients with confined liver disease or stable limited extrahepatic disease; * Lesions of 5cm or less in maximum diameter; * Patients who are not surgical candidates or refuse to undergo surgery and choose any percutaneous ablation as an alternative treatment option. * INR\<1.5 \*for patients on Coumadin general clinical guidelines for IR ablation will be followed. * Platelet count \> or = to 50,000 Exclusion Criteria: * Patients \< 18 * Less than 5 mm distance of the tumor margin from a major vessel \>7mm in diameter)\*\* * Less than 5 mm distance to a structure (GI or biliary tract), that cannot be protected from\*\* * the ablation injury with technical modifications such as hydro or air dissection. * INR \> 1.5 that cannot be corrected with fresh frozen Plasma\* * Platelet count of \<50,000 that cannot be corrected with transfusion. * Patient with more than 3 tumors treated with any percutaneous ablation * Patients with more than 5 sites of extrahepatic disease (including nodes and pulmonary nodules) * for patients on Coumadin general clinical guidelines for IR ablation will be followed \*\*This will not be considered an exclusion criteria when IRE or Microwave is used. * This will not be considered exclusion when IRE is used