Clinical Research Directory

Inclusion Criteria: * Patient aged 18 years old * Carcinoma oral cavity, pharyngolaryngeal or without lymphadenopathy door * Patient treated by one of the following diagrams * radiotherapy alone * postoperative radiotherapy + / - sensitized platinum (cisplatin or carboplatin) * ar chemoradiation 5-FU and platinum (the Cetuximab is not allowed) * diagram organ preservation (induction chemotherapy and radiotherapy in responders) * Untreated patients * Patient should receive conventional radiotherapy or tomotherapy * Adapted stomatological care * Life expectancy \> 3 months * WHO score \< 2 * Patient stable, not having the time of the examination of evidence of recurrent or progressive malignancy other * \- For patients with an indication of chemotherapy combined with radiotherapy,biological assessments compatible with chemotherapy: * WBC \> 3000/mm3, Polynuclear \> 2000/mm3,Platelets \> 150,000/mm3, Creatinine less than 2 times normal; Bilirubin less than 2.5 times normal * Patient fluent in French * Affiliation to a system of social security * Patient has given written consent Exclusion Criteria: * Patient with a history of malignancy, outside a basal cell carcinoma or cervical cancer treated and cured * Patient has at the time of examination signs of recurrence or other neoplasia scalable * Patient with a history of prior chemotherapy or radiation therapy with the exception of the scheme of organ preservation (induction chemotherapy before radiation) * For patients with an indication of chemotherapy combined with radiotherapy, contraindication to treatment with specific platinum (cisplatin or carboplatin) with or without 5 Fluorouracil * Infectious diseases uncontrolled * Patient is pregnant or lactating or absence of contraception during their reproductive * Patient hypertensive unbalanced under antihypertensive treatment * Uncontrolled cardiac disease * Patients with renal or hepatic * Known allergy to any component of Ialuset ® * Patient deprived of liberty under guardianship * Any medical condition or psychological associate that could compromise the patient's ability to participate in the study * Inability to undergo medical test for geographical, social or psychological