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Intraoperative Noradrenaline to Control Arterial Pressure (INPRESS Study)
Sponsor: University Hospital, Clermont-Ferrand
Summary
The purpose of this study is to evaluate whether a preventive strategy of intraoperative arterial hypotension using noradrenaline can reduce the incidence of postoperative organ failure.
Official title: Effectiveness of Noradrenaline to Control Intraoperative Arterial Pressure in High-risk Surgical Patients: A Multicentre Prospective Randomized Controlled Trial
Key Details
Gender
All
Age Range
50 Years - Any
Study Type
INTERVENTIONAL
Enrollment
300
Start Date
2012-03
Completion Date
2016-07
Last Updated
2026-08-10
Healthy Volunteers
No
Conditions
Interventions
noradrenaline
The primary objective of the study is to compare two strategies of intraoperative blood pressure management in high-risk surgical patients: 1- Continuous infusion of noradrenaline to maintain arterial blood pressure of no more than 10% below its baseline value; 2- Conventional treatment of hypotension (defined as a blood pressure of below 80 mmHg or a decrease of more than 40% from baseline) using intravenous bolus of Ephedrine chorhydrate.
Ephedryne chorydrate
Locations (1)
CHU Clermont-Ferrand
Clermont-Ferrand, France