Clinical Research Directory

Inclusion Criteria: * Group of patients * Patients older than 18 years, * Male or Female with BMI between 18 and 35, * Patients with chronic neuropathic pain for more than six months, except to diabetes or central neuropathic pain * Patients receiving systemic therapy for treating chronic neuropathic pain such as antidepressants, anticonvulsants or opiates for at least 6 months. Group of healthy volunteers * non-painful healthy volunteers matched by age, sex, BMI and menopausal status for women, * Free of analgesics within 8 days before the test, * Aged over 18 years, * Male or Female, Exclusion Criteria: * Subjects with a medical history and / or surgical judged by the investigator or his representative as being incompatible with the test * Patients treated only by topical treatment (lidocaine patch only for example) * Pateints receiving corticosteroid treatment at the time of enrollment, or who received such treatment during the last 6 months (regardless of the dosage form and dosage), * Inflammatory and evolutive pathology requiring long term treatment, * Type 2 diabetes, * Postmenopausal women with replacement therapy, * Weight change of more than 5% within 3 months before the study, * BMI \<18 or\> 35,