Clinical Research Directory

Inclusion Criteria: * Inclusion criteria for AD cases: * Diagnosis of probable AD, defined according to the NINCDS-ARDRA criteria51 * Light to moderate severity of the disease, defined by a MMSE score \>10 (global evaluation of cognition) * Patient aged 50 years or more * Patient benefiting from social insurance Inclusion criteria for controls: * Absence of suspicion of dementia, based on normal performance according to age and educational level at neuropsychological testing defined as: * Free recall ≥17 and total recall ≥40 for the Free and Cued Selective Reminding Test (Grober and Buschke test 52) MMSE ≥ norm for age and educational level (defined by mean - 1 SD) * Isaac's set test ≥ norm for age and educational level (defined by mean - 1 SD) * Matched to age and gender of the cases * Patient benefiting from social insurance Exclusion Criteria: Exclusion criteria for all patients : * History of Parkinson's disease or other neurodegenerative disorder * History of Horton's disease * History of inflammatory neuropathies (in particular Devic's disease, multiple sclerosis) * History of vascular ischemic neuropathies and chronic intracranial hypertension * History of pituitary tumors * Presence of diseases (systemic and/or ocular diseases) or behavioural or cognitive symptoms incompatible with eye examination * Known diabetes * Person under tutorship or curatorship, person unable to express consent Additional exclusion criteria for AD cases: * Dementia of other cause than AD * Severe AD, defined by MMSE score ≤ 10 Additional exclusion criteria for controls: * Presence of dementia, of whatever cause