Clinical Research Directory

Inclusion Criteria: * Patient admitted to emergency departments with trauma of upper or lower limbs (sprains, muscle contusions,…) associated with intensity moderate of acute pain (VAS between 4 and 6) which require infusion IV of paracetamol 1g. * Patient takes any chronic treatment which considered incompatible with study. * Patient between 18 and 60. * Male or female. * Sufficient cooperation and understanding to comply to the requirements of study. * Acceptance to give a written consent. * Affiliation at system of French social security. * Inscription or acceptation of inscription at national register of voluntaries participant at research Exclusion Criteria: * Against paracetamol-indication: hypersensitivity known at paracétamol, antecedent hepatitis B or C, severe renal insufficiency and liver failure. * Patient with medical or surgical antecedents. * Patient with progressive disease at balance of inclusion. * Alcoholism suspicion or toxicomany at intake. * Patient who presents any inflammation or ulcerative pathology about buccal mucosa. * Patient who refuses to ingest alcohol for personal reasons. * Woman in childbearing age not using effective contraceptive method, pregnant or lactating woman. * Patient who participated in another clinical trial, located in exclusion period or received benefits \> 4500 euros during 12 months before the beginning of trial. * Patient with cooperation and understanding insufficiency to comply to the requirements of protocol * Patient with social protection * No affiliation at system of French social security