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Diffuse Acute Respiratory Distress Syndrome (ARDS), Recruitment Maneuver, and sRAGE (DAMAGE Study)
Sponsor: University Hospital, Clermont-Ferrand
Summary
RAGE, the receptor for advanced glycation end products, is a novel marker of alveolar epithelial type I cell injury, and soluble RAGE (sRAGE) is elevated in the plasma and in the pulmonary edema fluid from patients with ALI/ARDS. Few data are available about the influence of ventilatory interventions on levels of sRAGE in the setting of ALI/ARDS. The purpose of this prospective monocentric randomized controlled cross-over study is to describe the effects of a recruitment maneuver (RM) on plasma sRAGE levels during diffuse ARDS.
Official title: Effects Of A Recruitment Maneuver On Plasma Levels of sRAGE, The Soluble Form of The Receptor For Advanced Glycation End Products, In Patients With Diffuse Acute Respiratory Distress Syndrome (ARDS)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
24
Start Date
2012-04
Completion Date
2013-10
Last Updated
2026-08-10
Healthy Volunteers
No
Conditions
Interventions
Recruitment Maneuver (RM) sham group
It 's when RM sequence precedes a shame evaluation period
Sham recruitment maneuver (RM) group
Group in which patients receive a sham sequence before the RM sequence
Locations (1)
CHU Clermont-Ferrand
Clermont-Ferrand, France