Clinical Research Directory
Browse clinical research sites, groups, and studies.
Self-directed Titrated Transdermal Nicotine Patch Versus Standard Treatment for Smoking Cessation
Sponsor: Ottawa Heart Institute Research Corporation
Summary
The primary aim of this research study is to determine whether titrated, patient-directed transdermal patch NRT, based on smoking history and symptoms of nicotine withdrawal, improves long-term rates of smoking cessation in patients motivated to quit smoking when compared to patients using the standard transdermal NRT patch protocol. The following hypothesis will be tested: CO-validated continuous abstinence rate at 52 weeks post target quit date will be higher for the titrated, self-directed NRT group compared to the standard NRT treatment group.
Official title: Self-directed Titrated Transdermal Nicotine Patch Versus Standard Treatment for Smoking Cessation in Smokers Motivated to Quit
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
303
Start Date
2011-01
Completion Date
2014-09
Last Updated
2026-08-14
Healthy Volunteers
Yes
Conditions
Interventions
NicoDerm Patch
Dosage: 21mg patch; 14mg patch; 7 mg patch Frequency: NRT patch application once per day Duration: 10 week treatment period \*Titration for experimental group (NRT+) based on smoking history, and option to increase dose if withdrawal symptoms are unmanageable.
Nicorette Inhaler
Nicorette Inhaler: Box, 42 cartridges (4mg/cartridge) Dosage: Ad libitum Maximum dosage: 6-12 cartridges/day
Locations (1)
University of Ottawa Heart Institute
Ottawa, Ontario, Canada