Inclusion Criteria:
* Diagnosis of acute myeloid leukemia (AML) as defined by the World Health Organization
* Molecular AML-risk group is less-than-favorable as defined by any of the following criteria:
* The absence of good-risk karyotype t(8;21), inv(16), t(16;16), or t(15;17)identified by metaphase karyotype
* The absence of t(8;21), inv(16), t(16;16), or t(15;17) identified by fluorescent in situ hybridization(FISH)
* The absence of the corresponding fusion transcripts, AML1-eight-twenty-one corepressor (ETO), core-binding factor, beta subunit (CBFβ)-smooth muscle myosin heavy chain (SMMHC), or progressive multifocal leukoencephalopathy (PML)-retinoic acid receptor alpha (RARa), identified by reverse transcriptase-polymerase chain reaction (RT-PCR)
* Patient does not have acute promyelocytic leukemia (APL, French-American-British \[FAB\] M3)
* Eastern Cooperative Oncology Group (ECOG) performance status ≤ 2 (Karnofsky ≥ 60%)
* Adequate cardiac function as defined by either of the following:
* An echocardiogram demonstrating an ejection fraction within normal limits
* A multi gated acquisition (MUGA) scan demonstrating an ejection fraction within normal limits
* Aspartate aminotransferase (AST)(serum glutamic oxaloacetic transaminase \[SGOT\])/alanine aminotransferase (ALT)(serum glutamate pyruvate transaminase \[SGPT\]) ≤ 2.5 times institutional upper limit of normal (ULN)
* Creatinine ≤ 2 mg/dL OR creatinine clearance ≥ 50 mL/min
* Total bilirubin ≤ 2 times ULN
* Patients with documented diagnosis of Gilbert syndrome resulting in elevated total bilirubin levels will be eligible, provided all other eligibility criteria are met
* Patients with a total bilirubin of 2-3 mg/dL and direct (conjugated) bilirubin in the normal range will be eligible, provided all other eligibility criteria are met
* Pregnant and nursing subjects may not be enrolled and pregnancy must be avoided; women of child-bearing potential-defined as a sexually active woman who has not undergone hysterectomy and who has had menses any time within the preceding 24 months-must have a negative serum or urine pregnancy test within 7 days prior to registration; women and men of childbearing potential must either commit to continued abstinence from heterosexual intercourse or commit to two acceptable methods of birth control-one highly effective method (e.g., IUD, oral or non-oral hormonal contraceptive, tubal ligation or partner's vasectomy) and one additional effective method (e.g., latex condom, diaphragm or cervical cap) at the same time from the time of screening through final Treatment Response Assessment
* NOTE: should a woman become pregnant or suspect she is pregnant while she or her partner is participating in this study, the subject should inform their treating phy-sician immediately
* NOTE: the effects of decitabine on the developing human fetus are unknown but it is a know teratogen in mammals (mice)
* Ability to understand and the willingness to sign a written informed consent document
Exclusion Criteria:
* Chemotherapy (other than hydroxyurea) or radiation within the 2 weeks prior to planned therapy on this study or ongoing adverse events due to agents administered more than 2 weeks earlier
* Concurrent treatment with other investigational agents is not permitted
* Cumulative lifetime dose of anthracycline chemotherapeutic \> 80 mg/m\^2
* History of allergic reactions attributed to compounds of similar chemical or biologic composition of decitabine, cytarabine or daunorubicin
* Uncontrolled intercurrent illness considered by the investigator to constitute an unwarranted high risk for investigational drug treatment; examples include, but not limited to the following:
* Uncontrolled serious infection; or
* Unstable angina pectoris; or
* Uncontrolled cardiac arrhythmia; or
* Active second malignancy requiring treatment; or
* Symptomatic congestive heart failure
* HIV-positive subjects with a CD4 count \< 200 cells/μL are excluded due to the increased risk of lethal infections when treated with marrow-suppressive chemotherapy(87)
* NOTE: subjects with HIV infection and a CD4 count \>= 200 cells/μL are eligible but combination antiretroviral therapy should be held during administration of chemotherapy due to the potential for pharmacokinetic interactions with decita-bine, cytarabine or daunorubicin. Antiretroviral therapy may be resumed 24 hours after completion of the last dose of induction chemotherapy
* Subject has a psychiatric disorder, altered mental status or social situation that would preclude understanding of the informed consent process and/or limit compliance with study requirements
* Subject has an inability or unwillingness, in the opinion of the investigator, to comply with the protocol requirements
* Subjects with central nervous system (CNS) (or leptomeningeal) infiltration by AML may be considered for treatment at the Investigator's discretion and following discussion with the Principle Investigator; all neurologic deficits must be noted prior to enrollment on study
* Subject has circulating blast count \> 50,000/μL (subjects may be enrolled if circulating blast count is controlled by hydroxyurea and/or, if clinically indicated, by leukophoresis)
