Clinical Research Directory
Browse clinical research sites, groups, and studies.
Investigating Serotonin Signalling in IBD Patients
Sponsor: McMaster University
Summary
Alterations in normal serotonin (5-hydroxytryptamine;5-HT) signaling have been reported in ulcerative colitis (UC) and Crohn's disease (CD). Studies report an increase in enterochromaffin (EC) cell, main source of 5-HT in the gut, numbers in CD and UC patients. Up-regulated expression of mucosal Tryptophan hydroxylase (TPH)-1, catalytic enzyme in 5-HT production, messenger RNA (mRNA) have been found in CD patients in remission who are suffering the irritable bowel syndrome (IBS)-like symptoms. Alterations in normal 5-HT signaling has also been reported in animal models of inflammatory bowel disease (IBD). Thus, the aim of the proposed research project will be to study the alterations in 5-HT signalling accompanying GI inflammatory conditions, such as IBD.
Key Details
Gender
All
Age Range
19 Years - 85 Years
Study Type
OBSERVATIONAL
Enrollment
60
Start Date
2012-07
Completion Date
2026-05
Last Updated
2024-11-20
Healthy Volunteers
Yes
Conditions
Locations (1)
McMaster University Medical Center
Hamilton, Ontario, Canada