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Molecular Mechanisms of Dutasteride and Dietary Interventions to Prevent Prostate Cancer and Reduce Its Progression
Sponsor: CHU de Quebec-Universite Laval
Summary
The purpose of this study is to determine whether marine omega-3 fatty acids and 5-alpha-reductase inhibitor are effective in the progression of prostate cancer for low-risk prostate cancer patients.
Key Details
Gender
MALE
Age Range
35 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
120
Start Date
2010-10-28
Completion Date
2026-12
Last Updated
2025-11-24
Healthy Volunteers
No
Interventions
Dietary intervention first
The dietary intervention will be aimed to increase intake of ω-3 long chain fatty acids and to reduce intake of saturated and trans fatty acids. Three consultations with a nutritionist experienced in clinical trials will be planned over a 6-month period. An additional 2 consultations in the last 6 months with the study nutritionist will be planned for men allocated to the dietary fat intervention arm first. Then, after the 6 months of diet intervention, drug intervention with 5α-Reductase Inhibitor will be add to diet for the 6 following months.
Drug (Dutasteride) intervention first
5α-Reductase Inhibitor will be taken daily in tablet dosage form (0.5 mg) taken orally for 12 months depend of the group. After 6 months of drug intake, dietary fat intervention will be add to treatment for the following 6 months. Three consultations with a nutritionist experienced in clinical trials will be planned over this 6-month period.
Locations (2)
Hotel-Dieu of Quebec
Québec, Quebec, Canada
Institute of nutraceuticals and functional food of Laval University
Québec, Quebec, Canada