Clinical Research Directory

* INCLUSION CRITERIA: * Participant of the Environmental Polymorphisms Registry and current contact information available * Genotype information available for relevant 765G\>C and 8473T\>C COX2 polymorphisms, which indicates: * Individuals who are WT with respect to both 765G\>C and 8473T\>C (N=31) * Individuals who are WT with respect to 765G\>C and homozygous for 8473T\>C (N=31) * Individuals who are homozygous for both 765G\>C and 8473T\>C (N=31) * Age 18- 65 years * Race self-identified as White or Black and Non-Hispanic ethnicity * Willing and able to provide informed consent * Able to comply with all protocol procedures EXCLUSION CRITERIA: * History of infection within the preceding 1 week or an oral temperature \>38 degrees C * Current daily or chronic use of corticosteroids (systemic, inhaled and topical). * Any current conditions known to impact peripheral white blood cell count (e.g., leukemia, lymphopenia, AIDS, other immunodeficiency disorders) * Current daily or chronic use of systemic immunosuppressants. * Current pregnancy or lactation * Unwilling or unable to: * Fast (including alcohol and caffeine-containing products) and discontinue tobacco use for 12 hours prior to the study visit * Withhold all prescribed and over-the-counter medications and supplements the morning of the study visit, until after the visit is completed * Refrain from taking the following medications and supplements for 7 days prior to the study visit: * NSAIDs * Corticosteroids (nasal, inhaled, topical or systemic) * Fish oil and niacin supplements * For blood draws that exceed 200ml, a hematocrit of \<34% for women or \<36% for men, or \>56% for either gender. * For blood draws exceeding 200ml, blood or plasma donation in the last 8 weeks