Clinical Research Directory

Preparatory Phase Inclusion Criteria: * Primary diagnosis of OCD * Currently on a stable and adequate dose of a serotonin reuptake inhibitor (i.e., clomipramine, fluoxetine, fluvoxamine, sertraline, paroxetine, citalopram, escitalopram) but still have clinically significant OCD symptoms Exclusion Criteria: * Comorbid Psychiatric conditions that significantly elevate the risks of study participation (e.g. psychotic disorders, bipolar disorder, evidence of dementia or other cognitive disorder, suicidality) * Unstable medical conditions that need attention and would make participation in the study unsafe (e.g., very high blood pressure) * Patients who have already had prior adjunctive EX/RP (more than 8 sessions within 2 months) while receiving an adequate SRI trial * Patients taking other medications besides an SRI (e.g. antipsychotics, mood stabilizers, other antidepressants besides SRIs) * Patients who are pregnant, sexually active and not using contraception, or nursing Study Phase Inclusion Criteria: * Those who achieve mild to minimum OCD symptoms from Preparatory Phase will enter the Study Phase Exclusion Criteria: * All exclusions listed above for Preparatory Phase are exclusions for Study Phase as well * Patients who are depressed at the end of the Preparatory phase are excluded from Study Phase