Clinical Research Directory

Inclusion Criteria: * Generally healthy * Body mass index of between 19-24 kg/m2 * Normal folate, vitamin B12, and B6 status Exclusion Criteria: * Unable to swallow tablets * Unable to receive intravenous catheters * Use of vitamin supplements, amino acid or protein supplements for more than six months before study participation * Chronic consumption of a high-protein diet (e.g. Atkins Diet) * Medical conditions such as diabetes, asthma, cancer, cardiovascular disease, a history of neural tube defect (such as spina bifida) affected pregnancy, have had gastrointestinal surgery, abnormal kidney, thyroid function, or psychiatric illness, or any other chronic disease * Pregnancy or lactation * Smoking, use of recreational drugs, and/or consumption of more than one alcohol drink per day or more than seven per week. * Use of long-term prescription medication such as hormonal contraceptives, antidepressants, anticonvulsants, anticoagulants, or other chronic medication * Blood donation in the last three months prior to study start * Unable to provide informed consent, or unable to read and write English * Low compliance to intervention as determined by early steady-state or reduction in blood folate concentrations