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Sputum Cytometry Analysis in Lung Cancer Screening After Professional Asbestos Exposure
Sponsor: University Hospital, Caen
Summary
Workers exposed to asbestos are at high risk of lung cancer. Medical follow-up of this population relies on repeated CT-scans which are more accurate for detection of peripheral lesions, and expose to X-rays and to risk of false-positives. Analysis of sputum using automate cytometry may be of interest in this population, alone or in combination with CT-scan. An ancillary study will evaluate the interest of blood predictive biomarkers.
Official title: Interest of Morphometric Analysis of Sputum Cytology for Lung Cancer Screening in Workers Highly Exposed to Asbestos - Exploratory Analysis of Biomarkers Predictive for Lung Cancer
Key Details
Gender
All
Age Range
56 Years - Any
Study Type
INTERVENTIONAL
Enrollment
463
Start Date
2012-09
Completion Date
2020-10-14
Last Updated
2026-05-29
Healthy Volunteers
No
Conditions
Interventions
low-dose CT-scan AND induced sputum sample AND blood test
All subjects will receive a low-dose CT-scan, a blood test (ancillary study) and provide an induced sputum
Locations (3)
Caen University Hospital
Caen, France
Le Havre Hospital
Le Havre, France
Rouen University Hospital
Rouen, France