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Improvement Assessment of Coronary Flow Dysfunction Using Fundamental Fluid Dynamics
Sponsor: University of Cincinnati
Summary
Diagnosis of relative contributions of large artery blockages and microvascular blockages is very much needed in the treatment of coronary artery disease. In order to achieve this, two novel parameters, pressure drop coefficient (CDP), which combines flow and pressure readings and Lesion flow coefficient (LFC), which combines anatomical details of the lesion with pressure and flow readings, are being investigated.
Key Details
Gender
All
Age Range
18 Years - 100 Years
Study Type
OBSERVATIONAL
Enrollment
68
Start Date
2010-08
Completion Date
2025-07-30
Last Updated
2025-05-31
Healthy Volunteers
No
Conditions
Interventions
Cardiac PET, Coronary catheterization
Patients would under go a Cardiac rest and stress PET scan and include the following drug administration: 1. N-13 Ammonia radionuclide - Two doses, 10 mCi for rest, 20 mCi for stress 2. Lexiscan - stress agent for PET scan Patients would also undergo Coronary catheterization including the following drug administration and device usage: 1. Combowire to obtain pressure and flow readings on Combomap machine (Volcano Therapeutics, CA). 2. Adenosine - stress agent during catheterization, 140 ug/Kg/min
Locations (1)
Cincinnati Veteran Affairs Medical Center
Cincinnati, Ohio, United States