Clinical Research Directory

Inclusion Criteria: * Histologically confirmed high grade endometrial cancer including grade 3 endometroid, serous, clear cell, malignant mixed Mullerian tumor (MMMT) or any mixed tumor containing one of these cell types * Patients with a grade 1/2 tumors and evidence of deep myometrial invasion or cervical involvement on preoperative imaging or physical exam * Candidate for surgery * No evidence of peritoneal disease on preoperative imaging * Negative pregnancy test if of child-bearing age * No preoperative treatment for endometrial cancer including radiation or chemotherapy * Previous hormonal therapy is allowed Exclusion Criteria: * Medical co-morbidities making surgery unsafe, as determined by the primary treating physician * Any contraindications to PET/CT or lymph node mapping (inability to control serum glucose to a value of =\< 200 mg/dl for fludeoxyglucose F-18 \[FDG\]-PET/CT) * Does not meet histologic criteria * Evidence of peritoneal or distant metastasis on preoperative imaging * Baseline creatinine (necessary for imaging studies)