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Effects of Vitamin D and Omega-3 Fatty Acids on Infectious Diseases and hCAP18 (VITAL Infection)
Sponsor: Brigham and Women's Hospital
Summary
The VITamin D and OmegA-3 TriaL (VITAL; NCT 01169259) is an ongoing randomized clinical trial in 25,875 U.S. men and women investigating whether taking daily dietary supplements of vitamin D3 (2000 IU) or omega-3 fatty acids (Omacor® fish oil, 1 gram) reduces the risk of developing cancer, heart disease, and stroke in people who do not have a prior history of these illnesses. This ancillary study is being conducted among participants in VITAL and will examine whether vitamin D or omega-3 fatty acids affect risk of infection and plasma hCAP18 levels.
Official title: Effects of Vitamin D and Omega-3 Fatty Acids on Infectious Diseases and hCAP18
Key Details
Gender
All
Age Range
50 Years - Any
Study Type
INTERVENTIONAL
Enrollment
25874
Start Date
2010-07
Completion Date
2026-12
Last Updated
2025-09-25
Healthy Volunteers
Yes
Interventions
vitamin D3
Vitamin D3 (cholecalciferol), 2000 IU per day
omega-3 fatty acids (fish oil)
Omacor, 1 capsule per day. Each capsule of Omacor contains 840 milligrams of marine omega-3 fatty acids (465 mg of eicosapentaenoic acid \[EPA\] and 375 mg of docosahexaenoic acid \[DHA\])
Vitamin D3 placebo
fish oil placebo
Locations (1)
Brigham and Women's Hospital
Boston, Massachusetts, United States