Clinical Research Directory

Inclusion Criteria: 1. Provide written informed consent. 2. Be aged 18-45. 3. Report smoking cigarettes daily in the past 6 months. 4. Have expired breath CO indicative of regular smoking. 5. Have a score greater than 0 on the FTND. 6. Be willing to use Nicotine Replacement Therapy (NRT) and the e-cigarette for a period of 2 to 3 weeks. 7. Speak and read English. 8. Pass an MRI safety screen and meet inclusion criteria for MRI scans. Exclusion Criteria: 1. Be pregnant (measured via urinalysis). 2. Meet current abuse or dependence criteria for any substance other than nicotine or caffeine (measured via the SCID 5). 3. Produce a positive urine screen for drugs of abuse or alcohol at the fMRI scan visits. 4. Meet DSM-IV criteria for major depressive episode in the past six months, lifetime DSM-IV diagnosis of organic mental disorder, schizophrenia, schizoaffective disorder, bipolar disorder, delusional disorder or psychotic disorders not elsewhere classified (measured via the SCID 5). 5. Be currently suicidal as assessed by DSM 5 and the Beck Depression Inventory. 6. Current use of medications or any history of a medical condition that might affect the central nervous system at the time of scanning including: Abnormal structural MRI, or a history of head trauma or injury causing loss of consciousness lasting longer than 3 minutes or associated with skull fracture or intracranial bleeding or who had irremovable magnetically active objects on or within their body, history of epilepsy, current use of a beta-blocker or prescription analgesic/anxiolytic. (assessed by self-report). 7. MRI exclusion criteria. (additional information outlined in the "protection of human subjects" section). 8. History of claustrophobia. 9. History of propylene glycol sensitivity/allergy.