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HBRN: Immune Regulation and Costimulation in Natural History and Therapeutic Outcome of Chronic Hepatitis B
Sponsor: University of Pennsylvania
Summary
This is an ancillary to the NIDDK-sponsored treatment trials titled: Combination Therapy of Pegylated Interferon Alfa-2a and Tenofovir Versus Tenofovir Monotherapy in Chronic Hepatitis B (NCT01369212) and Combination Entecavir and Peginterferon Therapy in HBeAg-Positive Immune-Tolerant Adults With Chronic Hepatitis B (NCT01369199). This study will examine the balance between immune regulatory and effector responses in hepatitis B-infected participants enrolled in the HBRN's clinical trials (NCT01369212 and NCT01369199) to define natural history and treatment outcome.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
40
Start Date
2013-03
Completion Date
2026-12-01
Last Updated
2026-01-22
Healthy Volunteers
No
Conditions
Locations (8)
California Pacific Medical Center
San Francisco, California, United States
University of California San Francisco Medical Center
San Francisco, California, United States
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States
University of Minnesota
Plymouth, Minnesota, United States
Virginia Commonwealth University Medical Center
Richmond, Virginia, United States
Virginia Mason Medical Center
Seattle, Washington, United States
Harborview Medical Center
Seattle, Washington, United States
Toronto Western Hospital Liver Centre
Toronto, Ontario, Canada