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Myeloproliferative Neoplasms: an In-depth Case-control Study
Sponsor: Queen's University, Belfast
Summary
There is a paucity of data on the aetiology of myeloproliferative neoplasms (MPNs). The investigators conducted a systematic review of the literature which identified several cohort and case-control studies that have investigated a wide range of potential medical, environmental and occupational risk factors. However, these studies have been limited by a wide variation in case definition and small sample sizes limiting the potential to detect modest risk differences between cases and controls. The research group propose an exploratory case-control study of 100 patients with classic MPNs and 200 controls to determine the optimal methods for roll out of this study to a multi-centred UK-based case-control study that will investigate the aetiology of MPN subtypes. The objectives of the study are to evaluate recruitment procedures, response rates and the development of a telephone administered questionnaire. The findings of this exploratory study will form the basis of a protocol for a large United Kingdom (UK)-wide case-control study of MPNs.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
234
Start Date
2013-04-01
Completion Date
2015-06-30
Last Updated
2026-09-11
Healthy Volunteers
Yes
Interventions
Methodological pens
Randomisation of branded pen, non-branded pen and no pen
Methodological compensation
Randomisation of a £10 monetary reimbursement for expenses on completion of the study
Methodological trolley tokens
Trolley tokens to be randomly assigned to half of cases and General Practice controls.
Locations (3)
University Hospitals Southampton NHS Foundation Trust
Southampton, England, United Kingdom
Belfast Health And Social Care Trust
Belfast, Northern Ireland, United Kingdom
Queen's University Belfast
Belfast, Northern Ireland, United Kingdom