Clinical Research Directory

Inclusion Criteria: * Age between 18 and 70 years * Body mass index (BMI) between 27 and 45 kg/m2 Exclusion Criteria: * Report a heart condition, chest pain during periods of activity or rest, or loss of consciousness on the Physical Activity Readiness Questionnaire * Individuals reporting joint problems, prescription medication usage, or other medical conditions that could limit exercise will be required to obtain written physician consent to participate * Report being unable to walk for 2 blocks (1/4 mile) without stopping * Report major psychiatric diseases or organic brain syndromes. * Are currently participating in a weight loss program and/or taking weight loss or appetite regulation medication or lost \> 5% of body weight during the past 6 months * Have had bariatric surgery for weight loss or are planning to have bariatric surgery in the next 22 months * Intend to move outside of the metropolitan area within the time frame of the investigation * Are pregnant, lactating, \< 6 months post-partum, or plan to become pregnant during the investigation * Report not being able to consume meal replacements To participate in the weight loss maintenance phase, participants will need to lose equal to or greater than 8% of their body weight from the baseline measure at the conclusion of the 4-month weight loss phase.