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RECRUITING
NCT01851642

Lung Disease and Its Affect on the Work of White Blood Cells in the Lungs

Sponsor: University of Florida

View on ClinicalTrials.gov

Summary

The purpose of this study is to look at how Alpha-1-antitrypsin (AAT) deficiency and Cystic Fibrosis (CF) affect white blood cells in the lungs, called macrophages, and their ability to work.

Official title: The Role of Conformational Diseases on Macrophage Function

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

OBSERVATIONAL

Enrollment

220

Start Date

2007-08-09

Completion Date

2033-07-20

Last Updated

2025-11-06

Healthy Volunteers

Yes

Interventions

PROCEDURE

History and physical exam.

At every study visit, participant's will be asked about their medical history and will have a physical exam.

PROCEDURE

Blood draw.

At each study visit, participants will have an intravenous catheter (IV) placed in one of their veins and blood will be drawn from the IV for study testing.

PROCEDURE

Pulmonary function testing.

At every study visit, participants will have their lung function assessed. This is done by blowing forcefully at least 3 times into a tube. Testing will be done two times; before and after the use of an Albuterol inhaler.

DRUG

Albuterol inhaler.

At every study visit, participating subjects will take 2 puffs of an Albuterol inhaler after the first set of PFTs, but before the second set of PFTs. There will be at least a 30 minute period after the use of the Albuterol inhaler and the second set of PFTs.

Locations (1)

Shands at the University of Florida

Gainesville, Florida, United States