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Lung Disease and Its Affect on the Work of White Blood Cells in the Lungs
Sponsor: University of Florida
Summary
The purpose of this study is to look at how Alpha-1-antitrypsin (AAT) deficiency and Cystic Fibrosis (CF) affect white blood cells in the lungs, called macrophages, and their ability to work.
Official title: The Role of Conformational Diseases on Macrophage Function
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
220
Start Date
2007-08-09
Completion Date
2033-07-20
Last Updated
2025-11-06
Healthy Volunteers
Yes
Interventions
History and physical exam.
At every study visit, participant's will be asked about their medical history and will have a physical exam.
Blood draw.
At each study visit, participants will have an intravenous catheter (IV) placed in one of their veins and blood will be drawn from the IV for study testing.
Pulmonary function testing.
At every study visit, participants will have their lung function assessed. This is done by blowing forcefully at least 3 times into a tube. Testing will be done two times; before and after the use of an Albuterol inhaler.
Albuterol inhaler.
At every study visit, participating subjects will take 2 puffs of an Albuterol inhaler after the first set of PFTs, but before the second set of PFTs. There will be at least a 30 minute period after the use of the Albuterol inhaler and the second set of PFTs.
Locations (1)
Shands at the University of Florida
Gainesville, Florida, United States