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RECRUITING

NCT01851694

Beta-cell Response to Incretin Hormones in Cystic Fibrosis

Sponsor: University of Pennsylvania

View on ClinicalTrials.gov

Summary

In recent years, diabetes has emerged as one of the most significant co-diseases that many Cystic Fibrosis (CF) patients develop. Type 1 (T1D) and Type 2 (T2D) diabetes results when either the body does not make enough insulin or the body does not respond correctly to this insulin, respectively. Insulin is a hormone which is made by cells in the pancreas and helps carry glucose (sugar) from the food we eat to the cells of the body for energy. While cystic fibrosis related diabetes (CFRD) has many features similar to both T1D and T2D, patients with CF may not have the same symptoms as either T1D or T2D patients. Currently, there is little understanding of CFRD and the best options for treatment remain unclear. The purpose of this research study is to examine and understand the various mechanisms that contribute to CFRD and gain a better understanding of potential means to treat CFRD. In particular, we plan to study the effects of incretin hormones that can enhance insulin production in CF patients. Enrollment is complete for the protocol as initially written. In order to further study the role of the incretin hormone on Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) function , we have received approval to extend our investigation to include the following study groups: * Cystic Fibrosis participants with normal glucose tolerance * Non-Cystic Fibrosis controls

Official title: Determination of Beta-cell Responsiveness to the Incretin Hormones GLP-1 and GIP in Cystic Fibrosis

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

Start Date

2013-05

Completion Date

2026-12

Last Updated

2026-01-14

Healthy Volunteers

Yes

Conditions

Cystic Fibrosis Pancreatic Insufficiency

Interventions

DRUG

GLP-1

Each subject in this arm will receive GLP-1 infusion and a placebo infusion during a GPA test.

DRUG

GIP

Each subject in this arm will receive GIP infusion and placebo during a GPA test.

Inclusion Criteria: 1. Confirmed diagnosis of cystic fibrosis, defined by positive sweat test or CFTR mutation analysis according to CFF diagnostic criteria, 2. Age greater than or equal to 18y on date of consent 3. Pancreatic insufficiency 4. Recent OGTT consistent with Indeterminate-GT, IGT, CFRD w/o fasting hyperglycemia, or an established diagnosis of CFRD without fasting hyperglycemia 5. For female subjects, negative urine pregnancy test at enrollment. Control Subjects: 1. No history of cystic fibrosis. 2. Age ≥ 18y on date of consent. 3. Recent OGTT consistent with NGT. 4. For female subjects, negative urine pregnancy test at enrollment. Exclusion Criteria: 1. Established diagnosis of non-CF diabetes (i.e. T1D) or CFRD with fasting hyperglycemia (fasting glucose greater than126 mg/dL) 2. History of clinically symptomatic pancreatitis within last year 3. Prior lung or liver transplant 4. Severe CF liver disease, as defined by portal hypertension 5. Fundoplication-related dumping syndrome 6. Medical co-morbidities that are not CF-related or are unstable per investigator opinion (i.e. history of bleeding disorders, immunodeficiency) 7. Acute illness or changes in therapy (including antibiotics) within 6 weeks prior to study procedures 8. Treatment with oral or intravenous corticosteroids within 6 weeks of study 9. Hemoglobin less than10g/dL, within 90 days of Visit 1 or at Screening 10. Abnormal renal function, within 90 days of Visit 1 or at Screening; defined as Creatinine greater than 2x upper limit of normal (ULN) or potassium greater than 5.5mEq/L on non-hemolyzed specimen 11. Inability to perform study specific procedures (MMTT, GPA) 12. Subjects, who in study team opinion, may be non-compliant with study procedures. Control Subjects who will be exposed to GIP only: 1. History of clinically symptomatic pancreatitis. 2. History of liver disease. 3. History of any illness or condition that, in the opinion of the investigator might confound the results of the study or pose an additional risk to the subject. 4. Hemoglobin \<10g/dL, within 90 days of GPA test or at Screening. 5. Abnormal renal function, within 90 days of GPA test or at Screening; defined as creatinine \> 2x upper limit of normal (ULN) or potassium \> 5.5mEq/L on non-hemolyzed specimen. 6. Inability to perform study specific procedures (MMTT, GPA). 7. subjects, who in study team opinion, may be non-compliant with study procedures. 8. elevation of serum amylase or lipase \> 1.5x ULN within 90 days of GPA test.

Locations (1)

Children's Hospital of Philadelphia and University of Pennsylvania

Philadelphia, Pennsylvania, United States