Clinical Research Directory

Inclusion Criteria: * Patient is alive and has not received a transplant prior to enrollment in the study. * Under age 21 years at age of enrollment * For Group 1 (incident DCM), a case of DCM presenting to a study site within 2 years of the original cardiomyopathy diagnosis * Group 2 (incident/recent HCM), a new or existing diagnosis of idiopathic or familial HCM with a cMRI within 12 months of diagnosis * Group 3 (prevalent HCM or DCM), any child with a diagnosis of DCM or idiopathic, familial, or HCM due to a known disease-causing mutation who has survived transplant-free at least 12 months from the date of original cardiomyopathy diagnosis * For all 3 groups, diagnosis of cardiomyopathy must be confirmed by Echocardiographic or cMRI criteria Exclusion Criteria: A patient is not eligible for enrollment if one or more of the following conditions are met at the time of presentation with cardiomyopathy: * Any cardiomyopathy diagnosis other than DCM or idiopathic HCM, familial HCM or HCM due to a known disease-causing gene * Endocrine disease known to cause heart muscle disease (including infants of diabetic mothers) * History of rheumatic fever * Toxic exposures known to cause heart muscle disease (anthracyclines, mediastinal radiation, iron overload or heavy metal exposure) * HIV infection or born to an HIV positive mother * Kawasaki disease * Congenital heart defects unassociated with malformation syndromes (e.g., valvular heart disease or congenital coronary artery malformations) * Immunologic disease * Invasive cardiothoracic procedures or major surgery during the preceding month, except those specifically related to cardiomyopathy including left ventricular assist device (LVAD), extracorporeal membrane oxygenator (ECMO), and automatic implantable cardioverter defibrillator (AICD) placement * Uremia, active or chronic * Abnormal ventricular size or function that can be attributed to intense physical training or chronic anemia * Chronic arrhythmia, unless there are studies documenting inclusion criteria prior to the onset of arrhythmia (except a patient with chronic arrhythmia, subsequently ablated, whose cardiomyopathy persists after two months is not to be excluded) * Malignancy * Systemic Hypertension * Pulmonary parenchymal or vascular disease (e.g., cystic fibrosis, cor pulmonale, or pulmonary hypertension) * Ischemic coronary vascular disease * Association with drugs (e.g., growth hormone, corticosteroids, cocaine) or other diseases known to cause hypertrophy