Clinical Research Directory

Inclusion Criteria: * At least one blood culture positive for S. aureus * Patients aged ≥18 years * At least two of four systemic inflammatory response syndrome (SIRS) criteria on the day of positive blood cultures. SIRS criteria are: * Body temperature less than 36°C(96.8°F) or greater than 38°C(100.4°F) * Heart rate greater than 90 beats per minute * Tachypnea (high respiratory rate), with greater than 20 breaths per minute; or, an arterial partial pressure of carbon dioxide less than 32 mmHg * WBC less than 4000 cells/mm³ (4 x 109 cells/L) or greater than 12,000 cells/mm³ (12 x 109 cells/L); or the presence of greater than 10% immature neutrophils (band forms) Exclusion Criteria: * Sequential Organ Failure Assessment (SOFA) score \> 12 on day of positive blood cultures * Survival expected to be \< 7 days from positive blood cultures