Clinical Research Directory

Inclusion Criteria: 1. Patients \> = 18 years of age 2. Patients with hemoglobin \< = 8g/dL with with active bleeding, physiologic evidence of critical ischemia, for example: elevated troponins, altered mental status, acute renal failure, lactic acidosis or central nervous system supply dependency 3. Patients or their Legally Authorized Representatives who are able and willing to provide informed consent Exclusion Criteria: 1. Patients with known hypersensitivity or allergy to beef products 2. Patients with pre-existing uncontrolled hypertension, heart failure, renal failure, circulatory hypervolemia or systemic mastocytosis (on a case by case and quality of life determination) 3. Patients \> 80 years of age (on a case by case and quality of life determination) 4. Patients who are eligible for blood transfusions