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Intensity-Modulated Proton Beam Therapy or Intensity-Modulated Photon Therapy in Treating Patients With Stage III-IVB Oropharyngeal Cancer
Sponsor: M.D. Anderson Cancer Center
Summary
This randomized phase III trial studies the side effects and how well intensity-modulated proton beam therapy works and compares it to intensity-modulated photon therapy in treating patients with stage III-IVB oropharyngeal cancer. Radiation therapy uses high-energy x-rays, protons, and other types of radiation to kill tumor cells and shrink tumors. It is not yet known whether intensity-modulated proton beam therapy is more effective than intensity-modulated photon therapy in treating oropharyngeal cancer.
Official title: Phase III Randomized Trial of Intensity-Modulated Proton Beam Therapy (IMPT) Versus Intensity-Modulated Photon Therapy (IMRT) for the Treatment of Oropharyngeal Cancer of the Head and Neck
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
440
Start Date
2013-08-26
Completion Date
2031-12-31
Last Updated
2026-02-24
Healthy Volunteers
No
Conditions
Interventions
Intensity-Modulated Radiation Therapy
Undergo IMRT
Intensity-Modulated Radiation Therapy
Undergo IMPT
Laboratory Biomarker Analysis
Correlative studies
Photon Beam Radiation Therapy
Undergo IMRT
Proton Beam Radiation Therapy
Undergo IMPT
Quality-of-Life Assessment
Ancillary studies
Locations (22)
University of Alabama at Birmingham
Birmingham, Alabama, United States
Mayo Clinic in Arizona
Scottsdale, Arizona, United States
University of Florida Health Science Center - Gainesville
Gainesville, Florida, United States
Miami Cancer Institute
Miami, Florida, United States
Emory University Hospital/Winship Cancer Institute
Atlanta, Georgia, United States
Northwestern Medicine Cancer Center Warrenville
Warrenville, Illinois, United States
Willis-Knighton Medical and Cancer Center
Shreveport, Louisiana, United States
University of Maryland/Greenebaum Cancer Center
Baltimore, Maryland, United States
Massachusetts General Hospital Cancer Center
Boston, Massachusetts, United States
Wayne State University/Karmanos Cancer Institute
Detroit, Michigan, United States
Mayo Clinic in Rochester
Rochester, Minnesota, United States
New York Proton Center
New York, New York, United States
Memorial Sloan Kettering Cancer Center
New York, New York, United States
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, United States
University of Pennsylvania/Abramson Cancer Center
Philadelphia, Pennsylvania, United States
MD Anderson in The Woodlands
Conroe, Texas, United States
M D Anderson Cancer Center
Houston, Texas, United States
MD Anderson West Houston
Houston, Texas, United States
MD Anderson League City
League City, Texas, United States
MD Anderson in Sugar Land
Sugar Land, Texas, United States
Inova Schar Cancer Institute
Fairfax, Virginia, United States
Fred Hutch/University of Washington Cancer Consortium
Seattle, Washington, United States