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Bone Loss in Patients With Anorexia Nervosa
Sponsor: University Hospital, Montpellier
Summary
Nutritional deprivation of adolescent girls with anorexia nervosa (AN) reduces the bone mass acquisition. A better understanding of this process would improve the medical treatment of bone alteration and its long-term consequences. 160 patients (age \< 38 yr) with AN and 160 age-matched controls (CON) will be enrolled in this study. The areal bone mineral density (aBMD) will be determined using dual-X-ray absorptiometry. Calciotropic hormones, bone turnover markers will be concomitantly evaluated.
Official title: Physiopathology of Bone Loss in Young Patient With Anorexia Nervosa
Key Details
Gender
FEMALE
Age Range
14 Years - 38 Years
Study Type
INTERVENTIONAL
Enrollment
320
Start Date
2011-09
Completion Date
2017-04-25
Last Updated
2026-06-12
Healthy Volunteers
Yes
Conditions
Interventions
clinical parameters description
description of weight, height, Bone Mass Index, dietary questionnary, amenorrhea time, pathology time for the two arms
para clinical parameters description
description of DMO, mass, basal metabolism, IGF-1/IGFBP-3 for the two arms
hormonal parameters dosing
dosing of leptine, leptine receptor, adiponectine, ghreline for the two arms
bone modeling markers dosing
dosing of osteocalcine, bone alkalin phosphatase, C-telopeptide of type-I collagene, osteoprotegerine/ RANKL for the two arms
Locations (1)
CHU de Montpellier - Département d'Endocrinologie Diabète
Montpellier, France