Clinical Research Directory

Inclusion Criteria: * Patient capable of giving informed consent * Patient diagnosed with hepatocellular carcinoma and listed or recommended to be listed for orthotopic liver transplantation at the participating institution * Age \> 18 years old * Meets clinical criteria for eligibility for TACE to the target lesion per Interventional Radiology * Childs' Class A or B7 * Eastern Clinical Oncology Group performance status 0 or 1 Exclusion Criteria: * Prior radiotherapy to the upper abdomen or radioembolization of the liver * Prior TACE to the target lesion, RFA, or liver transplant * Active GI bleed within 2 weeks of study enrollment * Active GI ulcer disease within 4 weeks of study enrollment * Ascites refractory to medical therapy * Contraindication to receiving radiotherapy or TACE * Complete obstruction of portal venous flow to the segment of liver that includes the target lesion * Contraindication to both contrast enhanced MRI and contrast enhanced CT (i.e. unable to undergo follow-up imaging or SBRT treatment planning) * Women who are pregnant * Participation in another concurrent treatment protocol