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Adcetris (Brentuximab Vedotin), Combination Chemotherapy, and Radiation Therapy in Treating Younger Patients With Stage IIB, IIIB and IV Hodgkin Lymphoma
Sponsor: St. Jude Children's Research Hospital
Summary
This pilot phase II trial studies how well giving brentuximab vedotin, combination chemotherapy, and radiation therapy works in treating younger patients with stage IIB, IIIB or IV Hodgkin lymphoma. Monoclonal antibodies, such as brentuximab vedotin, can block cancer growth in different ways. Some block the ability of cancer to grow and spread. Others find cancer cells and help kill them or carry cancer killing substances to them. Drugs used in chemotherapy, such as etoposide, prednisone, doxorubicin hydrochloride, cyclophosphamide, and dacarbazine, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high-energy x-rays to kill cancer cells. Giving brentuximab vedotin with combination chemotherapy may kill more cancer cells and reduce the need for radiation therapy.
Official title: Adcetris (Brentuximab Vedotin), Substituting Vincristine in the OEPA/COPDac Regimen [Treatment Group 3 (TG3) of Euro-Net C1] With Involved Node Radiation Therapy for High Risk Pediatric Hodgkin Lymphoma (HL)
Key Details
Gender
All
Age Range
Any - 18 Years
Study Type
INTERVENTIONAL
Enrollment
77
Start Date
2013-08-12
Completion Date
2028-05
Last Updated
2025-12-03
Healthy Volunteers
No
Conditions
Interventions
brentuximab vedotin
Given intravenously (IV).
etoposide
Given IV.
prednisone
Given orally (PO).
doxorubicin
Given IV.
cyclophosphamide
Given IV.
Dacarbazine(R)
Given IV.
filgrastim
Given subcutaneously (SQ) as clinically indicated.
quality of life assessment
Quality of life assessment will be done at initial clinical visit, and during chemotherapy, completion of therapy, then at 1 year, 2 years and 5 years. It should take no more than 15-20 minutes to complete. Participation is voluntary by participating institution and by participant.
radiation therapy
At the end of chemotherapy and recovery of blood counts, radiotherapy will be given to any involved nodes (if any) that are not in complete remission.
Locations (6)
Lucile Packard Children's Hospital Stanford University
Palo Alto, California, United States
St. Jude Midwest Affiliate
Peoria, Illinois, United States
Maine Children's Cancer Program (MCCP)
Scarborough, Maine, United States
Massachusetts General Hospital Cancer Center
Boston, Massachusetts, United States
Dana-Farber Harvard Cancer Center
Boston, Massachusetts, United States
St. Jude Children's Research Hospital
Memphis, Tennessee, United States