Clinical Research Directory

Inclusion Criteria: * Upper tier intermediate risk with at least 2 of the following factors 1. Tumor-Nodes-Metastases Tumor stage T2B or greater 2. Gleason Score 7 3. PSA \> 10 4. \> 50% of the biopsies positive * OR High risk prostate cancer with one of the following factors 1. T3a 2. Gleason Score8-10 3. PSA \>20 * Positive prostate biopsy within 12 months (reviewed centrally) * International Prostate Symptom Score \< 16 * Prostate volume \< 60 cc * Negative staging CT and Bone scan within 3 months prior to registration * History and physical examination within 90 days prior to registration * European Cooperative Oncology Group performance status 0-1 prior to registration * Age \>45 * Patient suitable for procedure under anesthesia Exclusion Criteria: * Prior invasive malignancy (except non melanoma skin cancer) unless disease-free for at least 3 years prior to registration * Previous prostatectomy, cryotherapy or High Intensity Focussed Ultrasound for prostate cancer * Previous pelvic irradiation or prostate brachytherapy