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Gamete Treatment to Correct Fertilization Failure
Sponsor: Weill Medical College of Cornell University
Summary
In this proposed research study, the investigators plan to assess the efficacy of gametes' (egg and sperm) treatment on fertilization as well as pre- and post-implantation embryo development.
Key Details
Gender
All
Age Range
21 Years - 89 Years
Study Type
INTERVENTIONAL
Enrollment
1200
Start Date
2007-09
Completion Date
2027-11-30
Last Updated
2025-12-17
Healthy Volunteers
No
Conditions
Interventions
gamete treatment
Patient specimen will be selected through a synthetic, sterile, single-use, culture-tested mesh. The specimen will then be placed in a 37°C environment. After 30 minutes, the selected portion is retrieved from the other side of the mesh. The spermatozoa will be prepared in the standard fashion and utilized for injection or intrauterine insemination after exposure to a membrane permeabilizing agent. Human recombinant PLC-zeta will also be used if the spermatozoa have been confirmed to be PLC-zeta deficient. The injected oocytes will then be exposed to activating agents for the purpose of inducing embryo development. The oocyte activating agent is calcium ionophore and for sperm membrane permeabilization to assist in sperm DNA decondensation is streptolysin O (SLO).
Locations (1)
Center fo Reproductive Medicine
New York, New York, United States