Clinical Research Directory

Inclusion Criteria: * PATIENTS: * Diagnosis of advanced cancer (defined as locally advanced, metastatic, recurrent, or incurable disease) * Admitted to Acute Palliative Care Unit (APCU) * Delirium as per the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV- TR) criteria * Hyperactive/mixed delirium with RASS \>= 2 in the last 24 hours * On scheduled haloperidol of =\< 8 mg in the last 24 hours * Legally authorized representative consent * FAMILY CAREGIVERS: * Patient's spouse, adult child, sibling, parent, other relative, or significant other (defined by the patient as a partner) * Age 18 or older * At the patient's bedside at least 4 hours each day during patient delirium episode * Patients and family caregivers able to communicate in English or Spanish Exclusion Criteria: * PATIENTS * History of myasthenia gravis or acute narrow angle glaucoma * History of neuroleptic malignant syndrome * History of Parkinson's disease or dementia * Uncontrolled seizure disorder * History of hypersensitivity to haloperidol or benzodiazepine * On regular doses of benzodiazepine or chlorpromazine within the past 48 hours * Previously documented and persistent corrected QT (QTc) prolongation (\> 500 ms) * Heart failure exacerbation at the time of enrollment