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Re-irradiation of Recurrent Head and Neck Cancer
Sponsor: Technische Universität Dresden
Summary
The goal of this observational study is to evaluate the toxicity and local tumor control of proton therapy for patients with head and neck cancer in a previously irradiated field. Standard of care for recurrent or secondary malignancies in a previously irradiated field is surgery. For inoperable patients or residual tumor after surgery, standard of care would be palliative chemotherapy. For a small subset of patients (good performance status, small radiation fields) re-irradiation can be performed. In this study the established concept of re-irradiation with photons will be transferred to proton radiotherapy. Proton therapy has the advantage of a steeper dose gradient to normal tissues, thus-theoretical advantages for lower toxicity.
Official title: Observational Study to Re-irradiation for Recurrent Head and Neck Cancer
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
50
Start Date
2015-07
Completion Date
2026-12
Last Updated
2025-02-06
Healthy Volunteers
No
Conditions
Interventions
Radiation therapy
Radiation therapy with protons
Locations (1)
Dresden University of Technology, University Hospital Carl Gustav Carus, Department of Radiation Therapy and Radiation Oncology; and DKTK partner site Dresden
Dresden, Saxony, Germany