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Brain Functional MRI in Older Women With Breast Cancer (Brain fMRI-BC)
Sponsor: City of Hope Medical Center
Summary
This study will use advanced MRI techniques to characterize the changes that occur to the structure and functionality of the brain in older breast cancer patients receiving adjuvant chemotherapy, and determine the relationship between the brain changes and severity of chemotherapy toxicity. Our results will be an early step towards identifying neuroimaging markers of aging, breast cancer and chemotherapy treatment, and will contribute to our understanding of the underlying pathophysiology of cognitive changes and chemotherapy toxicity in vulnerable, older adults with cancer. Furthermore, the work will lay the foundation for future, larger scale clinical studies of cognitive changes and chemotherapy toxicity in the aging cancer population.
Official title: A Pilot Study of Structural and Functional Brain Magnetic Resonance Imaging Findings of Chemotherapy Toxicity in Older Women With Breast Cancer
Key Details
Gender
FEMALE
Age Range
65 Years - Any
Study Type
OBSERVATIONAL
Enrollment
49
Start Date
2013-09-30
Completion Date
2026-11-30
Last Updated
2026-01-28
Healthy Volunteers
No
Conditions
Locations (2)
City of Hope Medical Center
Duarte, California, United States
South Pasadena Cancer Center
South Pasadena, California, United States