Clinical Research Directory

Inclusion Criteria: For the purpose of this study, "musculoskeletal complaint" is defined as any new joint / muscular symptoms, including (but not limited to) * Rotator cuff tendonitis / subacromial bursitis * Carpal tunnel syndrome * Tendonitis e.g. epicondylitis "New" complaint is defined as a symptom in which the patient has not previously reported to their GP. GP and Musculoskeletal referred patients: Subject must fulfil all of the following conditions or characteristics in order to be considered for study enrolment or participation: 1. Is age \> 18 years 2. Has a new musculoskeletal complaint or has a family member with RA 3. Is capable of understanding and signing an informed consent form Rheumatology Clinic referred patients: Subject must fulfil all of the following conditions or characteristics in order to be considered for study enrolment or participation: 1. Is age \> 18 years 2. Has a new musculoskeletal complaint 3. Is capable of understanding and signing an informed consent form 4. Has tested CCP Ab positive Exclusion Criteria: GP and Musculoskeletal referred patients: Subjects with any of the following conditions or characteristics will be excluded 1. Patients with clinical synovitis 2. Patient fulfils 1987 ACR Criteria or the 2010 ACR/EULAR criteria for RA 3. For the MRI imaging component, the following exclusions will apply; pacemaker, surgical clips within the head, certain inner ear implants, neuro-electrical stimulators or metal fragments within the eye or head or eGFR \< 45 ml/min/1.73 m2. In patients with previous penetrating trauma to the eye, or patients at high risk of previous metal foreign body injury to the eye (e.g. welding), skull x-ray will be performed; these patients may be included in the absence of residual metal fragments on x-ray. Rheumatology clinic referred patients: Subjects with any of the following conditions or characteristics will be excluded 1. Patient has tested CCP Ab negative 2. Patient fulfils 1987ACR Criteria or the 2010 ACR/EULAR criteria for RA 3. For the MRI imaging component, the following exclusions will apply; pacemaker, surgical clips within the head, certain inner ear implants, neuro-electrical stimulators or metal fragments within the eye or head or eGFR \< 45 ml/min/1.73 m2. In patients with previous penetrating trauma to the eye, or patients at high risk of previous metal foreign body injury to the eye (e.g. welding), skull x-ray will be performed; these patients may be included in the absence of residual metal fragments on x-ray.