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Enhancing the Anabolic Effect of Perioperative Nutrition With Insulin While Maintaining Normoglycemia
Sponsor: McGill University Health Centre/Research Institute of the McGill University Health Centre
Summary
The purpose of this study is to find out whether adding insulin after current colorectal cancer surgery promotes making and keeping proteins in the body, and to find out whether or not this effect can be further increased by increasing the amount of protein given.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
0
Start Date
2013-12
Completion Date
2024-04
Last Updated
2026-10-08
Healthy Volunteers
No
Conditions
Interventions
Travasol (amino acid injection)
an amino acid supplementation infused intravenously containing essential and non-essential amino acids
Insulin
After the insertion of an arterial catheter and obtaining a baseline arterial blood glucose value, 2 units of insluin will be administered iv followed by an infusion of 2 microunits/kg\*min. Ten minuts after starting the insulin, and when the the blood glucose is\<6 mmol/L, dextrose 20% supplemented with phosphate (30mmol/L) will be infused. Blood glucose levels measured every 15 minutes and the dextrose infusion rate adjusted to maintain arterial glycemia between 4 and 6 mmol/L until end of study.
Locations (1)
McGill University Health Centre (MUHC) - Royal Victoria Hospital
Montreal, Quebec, Canada