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Multicenter Prospective Cohort Study on Current Treatments of Legg-Calvé-Perthes Disease
Sponsor: Texas Scottish Rite Hospital for Children
Summary
Legg-Calvé-Perthes disease is a childhood hip disorder which is common enough to be a significant public health problem (affects 1 in 740 boys between ages 0-14), but uncommon enough to have a sufficient number of patients from a single institution to perform a definitive prospective study comparing the results of current treatments. The present study will establish a database of prospectively identified patients with Legg-Calvé-Perthes (LCP) Disease and collect information regarding their presentation, treatment, and outcomes in the course of receiving currently available treatments. This study seeks to compare the outcomes of current treatments in the management of different age groups (ages 1-6, 6-8, 8-11, \>11) of patients with Perthes disease at two- and five-year followup and at skeletal maturity. For each age group, two to three common treatment regimens currently used by practicing pediatric orthopaedic surgeons will be compared. The intervention a patient receives is determined through physician treatment expertise, and is not pre-determined by the study.
Key Details
Gender
All
Age Range
1 Year - 18 Years
Study Type
OBSERVATIONAL
Enrollment
1500
Start Date
2012-08
Completion Date
2032-09
Last Updated
2025-05-06
Healthy Volunteers
No
Conditions
Interventions
Osteotomy + Long Term Non-Weight Bearing
Surgical procedure that improves femoral head containment, plus a post-operative protocol that requires patient to maintain non-weight bearing for 6 months.
Osteotomy + Short Term Non-Weight Bearing
Surgical procedure that improves femoral head containment, plus a post-operative protocol that allows early return to function after 6 weeks of non-weight bearing.
Nonoperative Observation
Group will not undergo any surgical or invasive procedures during course of treatment.
Multiple Epiphyseal Drilling
Multiple epiphyseal drilling is a procedure that creates small holes in the femoral head growth plate to increase blood flow into the femoral head.
Locations (46)
Children's Hospital of Alabama
Birmingham, Alabama, United States
Children's Hospital of Los Angeles
Los Angeles, California, United States
Kaiser Permanente Hospital
Los Angeles, California, United States
Rady Children's Hospital California
San Diego, California, United States
UCSF Benioff Children's Hospitals
San Francisco, California, United States
Children's Hospital Colorado
Aurora, Colorado, United States
Connecticut Children's Medical Center
Hartford, Connecticut, United States
Alfred I. DuPont Hospital for Children of the Nemours Foundation
Wilmington, Delaware, United States
Children's National Medical Center
Washington D.C., District of Columbia, United States
Children's Orthopaedics of Atlanta
Atlanta, Georgia, United States
Ann & Robert H. Lurie Children's Hospital of Chicago
Chicago, Illinois, United States
Johns Hopkins
Baltimore, Maryland, United States
Children's Hospital Boston
Boston, Massachusetts, United States
Mayo Clinic
Rochester, Minnesota, United States
Gillette Children's Specialty Healthcare
Saint Paul, Minnesota, United States
NYU Langone/Hospital for Joint Disease
New York, New York, United States
New York Presbyterian Hospital (Columbia Campus)
New York, New York, United States
Children's Hospital at Montefiore
The Bronx, New York, United States
OrthoCarolina
Charlotte, North Carolina, United States
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, United States
Nationwide Children's Hospital
Columbus, Ohio, United States
Oklahoma University Health Science Center
Oklahoma City, Oklahoma, United States
Oregon Health and Science University
Portland, Oregon, United States
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, United States
University of Tennessee-Campbell Clinic
Germantown, Tennessee, United States
Texas Scottish Rite Hospital for Children
Dallas, Texas, United States
Texas Children's Hospital
Houston, Texas, United States
Seattle Children's Hospital
Seattle, Washington, United States
Women and Children's Hospital of Adelaide
Adelaide, South Australia, Australia
Universidade de São Paulo
São Paulo, Brazil
Alberta Children's Hospital, Division of Paediatric Surgery
Calgary, Alberta, Canada
British Columbia Children's Hospital
Vancouver, British Columbia, Canada
Tianjin Hospital Pediatric Orthopedics
Tianjin, China
Children's Hospital Hamburg-Altona
Hamburg, Germany
Hospital of Schleswig-Holstein
Lübeck, Germany
University Hospital of Schleswig-Holstein (Campus Lubeck)
Lübeck, Germany
Kasturba Medical College (KMC), Manipal
Udupi, Karnataka, India
Children's Health Ireland at Temple Street
Dublin, Ireland
Oslo University Hospital
Oslo, Norway
Medical University of Lodz
Lodz, Poland
San Jorge Children's Hospital
San Juan, Puerto Rico
Hospital Infantil Universitario Nino Jesus
Madrid, Spain
Uppsala University
Uppsala, Sweden
Centre hopsitalier universitaire Vaudois
Lausanne, Switzerland
Alder Hey Children's Hosopital (University of Oxford)
Liverpool, United Kingdom
Southampton Children's Hospital
Southampton, United Kingdom