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Prostate Testing for Cancer and Treatment
Sponsor: University of Oxford
Summary
RATIONALE: Radical prostatectomy is surgery to remove the entire prostate. Radiation therapy uses high-energy x-rays or other types of radiation to kill tumor cells. Sometimes the tumor may not need treatment until it progresses. In this case, active surveillance may be sufficient. It is not yet known which treatment regimen is more effective for localized prostate cancer. PURPOSE: This randomized phase III trial is studying active monitoring to see how well it works compared with radical prostatectomy or radiation therapy in treating patients with localized prostate cancer.
Official title: The ProtecT Trial - Evaluating the Effectiveness of Treatments for Clinically Localised Prostate Cancer
Key Details
Gender
MALE
Age Range
50 Years - 69 Years
Study Type
INTERVENTIONAL
Enrollment
82849
Start Date
2001-06-01
Completion Date
2027-03-31
Last Updated
2022-11-14
Healthy Volunteers
Yes
Conditions
Interventions
Radical prostatectomy
radical prostatectomy
Conformal radiation therapy
Conformal radiation therapy, external beam
Active monitoring
Active monitoring of Prostate specific antigen levels and disease surveillance
Locations (8)
Queen Elizabeth Hospital
Birmingham, United Kingdom
Southmead Hospital
Bristol, United Kingdom
Addenbrokes' Hospital
Cambridge, United Kingdom
University Hospital of Wales
Cardiff, United Kingdom
Western General Hospital
Edinburgh, United Kingdom
Leicester General Hospital
Leicester, United Kingdom
Freeman Hospital
Newcastle, United Kingdom
Royal Hallamshire Hospital
Sheffield, United Kingdom