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Muscle Oxygenation, Type 1 Diabetes, and Glycated Hemoglobin
Sponsor: University Hospital, Lille
Summary
Most of the studies concerning aerobic fitness in Type 1 diabetic patients noted a relationship between impaired aerobic fitness and high glycated haemoglobin (HbA1c) levels, reflecting poor long term glycaemic control. To explain this relationship, the indirect effect of chronically high blood glucose levels on cardiovascular complications - and hence on exercise cardiovascular adaptations - are often mentioned. However, one could wonder if HbA1c could also have a direct impact on aerobic fitness patients with Type 1 diabetes. Haemoglobin glycation may increase its O2 affinity, thus limiting the O2 availability at the muscular level and impairing maximal aerobic power. Moreover, chronic hyperglycaemia might have deleterious effect on muscle mitochondrial capacity to use O2. The aim of this study is to assess the effect of Type 1 diabetes and of HbA1c level on muscular oxygen delivery and use and hence on aerobic fitness.
Official title: Impact of Type 1 Diabetes and Glycated Haemoglobin Levels on Oxygen Delivery and Release to Active Muscle During Exercise and on Muscle Oxidation Capacity - Possible Impact on Aerobic Fitness
Key Details
Gender
All
Age Range
18 Years - 40 Years
Study Type
OBSERVATIONAL
Enrollment
79
Start Date
2010-03
Completion Date
2013-12
Last Updated
2026-05-14
Healthy Volunteers
Yes
Conditions
Interventions
Incremental maximal exercise
The exercise test starts 2-4h after a standardised breakfast. After a 2-min resting period sitting on the cycle ergometer (Excalibur Sport, Lode B.V, Medical Technology, Groningen, Netherlands), the test starts at 30 watts with a 20 watts increment every 2min until exhaustion.
Oral Glucose Tolerance Test
The subjects arrive after an overnight fast and have a 75g Glucose Oral Charge.
Muscle biopsy
A sample of vastus lateralis (less than 150mg) is taken with a specific needle under local anesthesia.
Combined DLCO-DLNO
Lung carbon monoxide and nitric oxide diffusion capacities are assessed at rest in a sitting position.
Dual energy X-ray absorptiometry
Body composition is measured using dual energy X-ray absorptiometry at rest.
Accelerometry over one week
The subjects wear an uniaxial accelerometer over one week to assess their usual physical activity level
Questionnaires
Diet questionnaire, quality-of-life questionnaires, physical activity questionnaires
Locations (1)
CHRU Lille
Lille, France